丹麦宿主对有症状的诺如病毒（GGII.4）感染的遗传抗性
Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark.
作者信息
Kindberg Elin, Akerlind Britt, Johnsen Christina, Knudsen Jenny Dahl, Heltberg Ole, Larson Göran, Böttiger Blenda, Svensson Lennart
机构信息
Division of Molecular Virology, Medical Faculty, University of Linköping, Linköping, Sweden.
出版信息
J Clin Microbiol. 2007 Aug;45(8):2720-2. doi: 10.1128/JCM.00162-07. Epub 2007 May 30.
Abstract
A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
摘要
对丹麦五起诺如病毒爆发事件中的61名感染者，在FUT2基因的428和571核苷酸位点进行基因分型，以确定分泌型状态，即分泌物和黏膜中ABH抗原的存在情况。研究发现分泌型表型与症状性疾病之间存在强相关性（P = 0.003），扩展了先前的认知，并证实FUT2基因中的无义突变可预防症状性诺如病毒（GGII.4）感染。
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