Diarrheal Pathogens Research Unit (Dpru), Department of Medical Virology, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Gut Microbes. 2021 Jan-Dec;13(1):1979876. doi: 10.1080/19490976.2021.1979876.
The study tested the hypothesis that harboring high levels of histo-blood group antigen-expressing is a risk factor for norovirus diarrhea. The fecal abundance in diarrheic norovirus positive (DNP), non-diarrheic norovirus negative (NDNN), diarrhea norovirus negative (DNN), and non-diarrhea norovirus positive (NDNP) infants was determined by qPCR, and the risk of norovirus diarrhea was assessed by logistical regression. DNP infants contained significantly higher counts of than NDNN and DNN infants, = .0294, and 0.0001, respectively. The risk of norovirus diarrhea was significantly high in infants with higher counts of than those with lower counts, = .009. Harboring higher counts of is a risk factor for norovirus diarrhea.
高水平表达组织血型抗原的定植是诺如病毒腹泻的一个风险因素。通过 qPCR 确定腹泻性诺如病毒阳性（DNP）、非腹泻性诺如病毒阴性（NDNN）、腹泻性诺如病毒阴性（DNN）和非腹泻性诺如病毒阳性（NDNP）婴儿粪便中 的丰度，并通过逻辑回归评估诺如病毒腹泻的风险。DNP 婴儿的 含量明显高于 NDNN 和 DNN 婴儿， = 0.0294，分别为 0.0001。 的含量较高的婴儿患诺如病毒腹泻的风险显著高于 的含量较低的婴儿， = 0.009。因此， 定植水平较高是诺如病毒腹泻的一个风险因素。
