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儿童1,3-β-D-葡聚糖水平的定量分析：β-葡聚糖检测在儿科诊断应用中的初步数据。

Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting.

作者信息

Smith P Brian, Benjamin Daniel K, Alexander Barbara D, Johnson Melissa D, Finkelman Malcolm A, Steinbach William J

机构信息

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA.

出版信息

Clin Vaccine Immunol. 2007 Jul;14(7):924-5. doi: 10.1128/CVI.00025-07. Epub 2007 May 30.

DOI:10.1128/CVI.00025-07
PMID:17538119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1951061/
Abstract

1,3-Beta-D-Glucan serum levels have demonstrated good diagnostic sensitivity and specificity for the diagnosis of candidiasis in adult patients, but normal levels for children have not been established. We found higher 1,3-beta-D-glucan levels in children than those previously reported in adults.

摘要

1,3-β-D-葡聚糖血清水平已证明对成年患者念珠菌病的诊断具有良好的诊断敏感性和特异性，但儿童的正常水平尚未确定。我们发现儿童的1,3-β-D-葡聚糖水平高于先前报道的成人水平。

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本文引用的文献

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Evaluation of a (1->3)-beta-D-glucan assay for diagnosis of invasive fungal infections.用于诊断侵袭性真菌感染的（1->3）-β-D-葡聚糖检测法的评估
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Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome.β-D-葡聚糖作为侵袭性真菌感染的诊断辅助手段：在急性髓系白血病和骨髓增生异常综合征患者中的验证、临界值确定及性能评估
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Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients.血清葡聚糖水平对于重症监护病房患者是否存在真菌感染并无特异性。
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Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques.新生儿念珠菌血症与终末器官损害：运用荟萃分析技术对文献的批判性评估
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Positive (1-->3)-beta-D-glucan in blood components and release of (1-->3)-beta-D-glucan from depth-type membrane filters for blood processing.血液成分中的阳性（1→3）-β-D-葡聚糖以及用于血液处理的深层膜过滤器中（1→3）-β-D-葡聚糖的释放。
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Comparative study of mortality and morbidity in premature infants (birth weight, < 1,250 g) with candidemia or candidal meningitis.出生体重<1250克的早产婴儿念珠菌血症或念珠菌性脑膜炎的死亡率和发病率的比较研究。
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False-positive endotoxemia derives from gauze glucan after hepatectomy for hepatocellular carcinoma with cirrhosis.假阳性内毒素血症源于肝硬化肝细胞癌肝切除术后纱布葡聚糖。
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