Li Yanfeng, Zhang Jian
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Nutr Neurosci. 2007 Feb-Apr;10(1-2):51-8. doi: 10.1080/10284150701250747.
Low consumption of fruits and vegetable has been reported in individuals with psychiatric disorders. We tested the hypothesis that antioxidant vitamins and carotenoids rich in fruits and vegetable may be consequently low among attempters.
As a part of the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994, serum vitamins and carotenoids were measured in 6680 adults aged 17-39 years, who also completed a mental disorder diagnostic interview. Serum levels below gender-specific 1st quartile of the population were defined as low, otherwise as normal.
Compared with non-attempters, prevalence ratios (PRs) of low alpha-carotene, beta-cryptoxanthin in attempters were 1.45 (95% CI = 1.06-1.98) and 2.12 (1.47-3.08), respectively, the mean differences (nonattempter-attempter) of vitamin C, lutein/zeaxanthin and lycopene were 6.071 mmol/1 (SE = 1.948, p < 0.005), 0.041 micromol/l (0.015, p < 0.005) and 0.045 micromol/l (0.015, p < 0.005) respectively. Total carotenoid was significantly lower (PR = 2.34 (1.56-3.49) and mean difference = 0.142 (0.058) micromol/l). These differences were reduced by adjustment for fruit/vegetables consumption, vitamin supplementation and serum cotinine, but remain significant for beta-cryptoxanthin, lycopene and total carotenoids.
A history of attempted suicide is associated with low levels of antioxidant vitamins and carotenoids. Clinical importance of low antioxidants in attempters and interventional opportunity warrant further examination.
据报道，患有精神疾病的个体水果和蔬菜摄入量较低。我们检验了这样一个假设，即企图自杀者体内富含水果和蔬菜的抗氧化维生素和类胡萝卜素含量可能因此较低。
作为1988 - 1994年第三次全国健康与营养检查调查（NHANES III）的一部分，对6680名17 - 39岁的成年人进行了血清维生素和类胡萝卜素检测，这些人还完成了一次精神障碍诊断访谈。血清水平低于特定性别人口第一四分位数的被定义为低水平，否则为正常水平。
与未企图自杀者相比，企图自杀者中α - 胡萝卜素、β - 隐黄质水平低的患病率比值（PRs）分别为1.45（95%可信区间 = 1.06 - 1.98）和2.12（1.47 - 3.08），维生素C、叶黄素/玉米黄质和番茄红素的平均差异（未企图自杀者 - 企图自杀者）分别为6.071 mmol/1（标准误 = 1.948，p < 0.005）、0.041 μmol/l（0.015，p < 0.005）和0.045 μmol/l（0.015，p < 0.005）。总类胡萝卜素显著更低（PR = 2.34（1.56 - 3.49），平均差异 = 0.142（0.058）μmol/l）。通过对水果/蔬菜摄入量、维生素补充剂和血清可替宁进行校正后，这些差异有所减小，但β - 隐黄质、番茄红素和总类胡萝卜素的差异仍具有显著性。
自杀未遂史与抗氧化维生素和类胡萝卜素水平低有关。企图自杀者抗氧化剂水平低的临床重要性以及干预机会值得进一步研究。
