Wolin Kathleen Y, Grubb Robert L, Pakpahan Ratna, Ragard Lawrence, Mabie Jerome, Andriole Gerald L, Sutcliffe Siobhan
1Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL; 2Department of Surgery and Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO; 3Westat, Rockville, MD; and 4Information Management Services, Inc., Rockville, MD.
Med Sci Sports Exerc. 2015 Mar;47(3):581-92. doi: 10.1249/MSS.0000000000000444.
Benign prostatic hyperplasia (BPH) and its associated lower urinary tract symptoms (LUTS), including nocturia, are extremely common among middle- and older-age American men. Although studies on physical activity (PA) and prevalent BPH-related outcomes suggest that PA may protect against the development of this common condition, only a few studies have examined the relation between PA and incident BPH-related outcomes and LUTS with mixed findings. In addition, although nocturia is the most commonly reported and most bothersome LUTS in men with or without evidence of BPH, few studies have examined the association of PA and nocturia independent of BPH. The purpose of this analysis was to examine the association of PA with BPH-related outcomes and nocturia in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial.
We examined this association with both prevalent (n = 28,404) and incident (n = 4710) BPH-related outcomes (measured by self-report of physician diagnosis, BPH surgery, finasteride use, and clinical indicators) and nocturia. Poisson regression with robust variance was used to calculate prevalence ratios and relative risks.
PA was weakly positively associated with several prevalent BPH-related outcomes and was strongly inversely associated with prevalent nocturia. In incident analyses, PA was only associated with nocturia. Men who were active ≥1 h·wk(-1) were 13% less likely (95% confidence interval, 2%-22%) to report nocturia and 34% less likely (95% confidence interval, 15%-49%) to report severe nocturia as compared with men who reported no PA. The associations were similar for men with and without additional BPH-related outcomes, except for prevalent nocturia, where the association was stronger for men without other BPH-related outcomes.
Combined with other management strategies, PA may provide a strategy for the management of BPH-related outcomes, particularly nocturia.
良性前列腺增生（BPH）及其相关的下尿路症状（LUTS），包括夜尿症，在美国中老年男性中极为常见。尽管关于身体活动（PA）与BPH相关结局的研究表明，PA可能有助于预防这种常见疾病的发生，但仅有少数研究探讨了PA与新发BPH相关结局及LUTS之间的关系，且结果不一。此外，尽管夜尿症是有或无BPH证据的男性中最常报告且最困扰的LUTS，但很少有研究独立于BPH来探讨PA与夜尿症之间的关联。本分析的目的是在前列腺、肺、结肠和卵巢癌筛查试验中研究PA与BPH相关结局及夜尿症之间的关联。
我们研究了PA与现患（n = 28,404）和新发（n = 4710）BPH相关结局（通过医生诊断的自我报告、BPH手术、非那雄胺使用情况和临床指标衡量）以及夜尿症之间的这种关联。采用稳健方差的泊松回归来计算患病率比和相对风险。
PA与几种现患BPH相关结局呈弱正相关，与现患夜尿症呈强负相关。在新发分析中，PA仅与夜尿症相关。与报告无PA的男性相比，每周活动≥1小时的男性报告夜尿症的可能性降低13%（95%置信区间，2%-22%），报告严重夜尿症的可能性降低34%（95%置信区间，15%-49%）。对于有或无其他BPH相关结局的男性，这种关联相似，但现患夜尿症除外，在无其他BPH相关结局的男性中这种关联更强。
结合其他管理策略，PA可能为BPH相关结局，尤其是夜尿症的管理提供一种策略。
