Jiang Zhi-Yong, Zhang Xue-Mei, Zhou Jun, Zhang Feng-Xue, Chen Ji-Jun, Lü Yang, Wu Li, Zheng Qi-Tai
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, PR China.
Chem Pharm Bull (Tokyo). 2007 Jun;55(6):905-7. doi: 10.1248/cpb.55.905.
Two new sesquiterpenoids named alismorientols A (1) and B (2) were isolated from the rhizomes of Alisma orientalis collected in Sichuan province, People's Republic of China. Their structures were elucidated based on spectroscopic analyses (1D and 2D NMR data including HSQC, HMBC, COSY, and ROESY) and X-ray crystallographic analysis. Anti-hepatitis B virus (HBV) bioassay revealed that compound 1 showed moderate anti-HBV activity in vitro with IC50 for HBsAg: 1.1 microM, for HBeAg: 14.7 microM.
从中华人民共和国四川省采集的泽泻根茎中分离出两种新的倍半萜类化合物，分别命名为泽泻新醇A（1）和B（2）。基于光谱分析（包括HSQC、HMBC、COSY和ROESY的一维和二维核磁共振数据）和X射线晶体学分析确定了它们的结构。抗乙型肝炎病毒（HBV）生物活性测定表明，化合物1在体外表现出中等抗HBV活性，对HBsAg的IC50为1.1 microM，对HBeAg的IC50为14.7 microM。
