来自[具体来源未给出]的具有抗炎活性的新型C-17螺甾原萜烷型三萜类化合物，在Caco-2细胞中。 （原英文文本表述不太完整，可能影响准确理解，翻译仅供参考）
Novel C-17 spirost protostane-type triterpenoids from with anti-inflammatory activity in Caco-2 cells.
作者信息
Jin Qinghao, Zhang Jianqing, Hou Jinjun, Lei Min, Liu Chen, Wang Xia, Huang Yong, Yao Shuai, Hwang Bang Yeon, Wu Wanying, Guo Dean
机构信息
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Acta Pharm Sin B. 2019 Jul;9(4):809-818. doi: 10.1016/j.apsb.2019.04.002. Epub 2019 May 7.
Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds (-), were isolated from the of Linn. Structurally, alisolides A‒F (-), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H () is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I () represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of ‒, were further confirmed by the Mo(OAc)-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC values in the range of 0.76-38.20 μmol/L.
从地锦草中分离出21种结构各异的原萜烷型三萜类化合物，其中包括9种新化合物（-）。在结构上，泽泻醇A-F（-）由一个与五元环相连的氧杂环丁烷基团组成，代表了不寻常的C-17螺甾原萜烷型三萜类化合物。泽泻醇H（）是一种具有未报道的内过氧化物桥的新型三萜类化合物。泽泻醇I（）是23,24-缩醛三萜类化合物的首个实例。它们的结构通过光谱分析得以阐明，其中（-）、（）的绝对构型通过钼（乙酸盐）诱导的ECD方法进一步得到证实。此外，对所有分离物进行了评估，考察其对脂多糖诱导的Caco-2细胞中一氧化氮产生的抑制作用，所有化合物均表现出显著的抑制活性，IC值在0.76-38.20μmol/L范围内。
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