Yoneyama Satoko, Miura Katsuyuki, Sasaki Satoshi, Yoshita Katsushi, Morikawa Yuko, Ishizaki Masao, Kido Teruhiko, Naruse Yuchi, Nakagawa Hideaki
Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
J Epidemiol. 2007 May;17(3):86-92. doi: 10.2188/jea.17.86.
Inflammation has been established as a risk factor for cardiovascular diseases. The relationships of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids to inflammation are still controversial in Western populations. The relationships are not clear in Japanese whose intake of seafood-based long-chain n-3 PUFAs is high.
We conducted a cross-sectional epidemiologic study in the Japanese population (1,556 men and 1,461 women aged 35-60). Serum high sensitivity C-reactive protein (CRP) was measured, and intakes of 7 specific fatty acids (% of energy) were evaluated by a validated self-administered dietary history questionnaire.
CRP was significantly and inversely related to the intakes of oleic acid (p=0.008) and alpha-linolenic acid (p=0.026) in women after adjustment for confounding factors. A multiple regression analysis showed that, especially in the middle tertile of long-chain n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) intake, CRP was inversely related to the intake of oleic acid and linoleic acid in both sexes and to the intake of alpha-linolenic acid in women.
Intakes of oleic acid, linoleic acid, and alpha-linolenic acid would reduce serum CRP, especially when the intake of long-chain n-3 PUFAs is at a moderate level in Japanese.
炎症已被确认为心血管疾病的一个危险因素。在西方人群中，多不饱和脂肪酸（PUFAs）和单不饱和脂肪酸与炎症的关系仍存在争议。在以海鲜为基础的长链n-3多不饱和脂肪酸摄入量较高的日本人中，这种关系尚不清楚。
我们在日本人群（1556名男性和1461名年龄在35至60岁之间的女性）中进行了一项横断面流行病学研究。测量了血清高敏C反应蛋白（CRP），并通过一份经过验证的自填式饮食史问卷评估了7种特定脂肪酸的摄入量（占能量的百分比）。
在调整混杂因素后，女性中CRP与油酸摄入量（p = 0.008）和α-亚麻酸摄入量（p = 0.026）呈显著负相关。多元回归分析表明，尤其是在长链n-3多不饱和脂肪酸（二十碳五烯酸和二十二碳六烯酸）摄入量的中间三分位数时，CRP在男女中均与油酸和亚油酸摄入量呈负相关，在女性中与α-亚麻酸摄入量呈负相关。
在日本人中，油酸、亚油酸和α-亚麻酸的摄入量会降低血清CRP水平，尤其是当长链n-3多不饱和脂肪酸的摄入量处于中等水平时。
