Murakami Kentaro, Sasaki Satoshi, Takahashi Yoshiko, Uenishi Kazuhiro, Yamasaki Mitsuyo, Hayabuchi Hitomi, Goda Toshinao, Oka Jun, Baba Keiko, Ohki Kazuko, Muramatsu Kanako, Sugiyama Yoshiko
Nutritional Epidemiology Program, National Institutes of Health and Nutrition, Tokyo, Japan.
Nutr Res. 2008 May;28(5):309-14. doi: 10.1016/j.nutres.2008.03.008.
Little is known about the relation of dietary factors to circulating C-reactive protein (CRP) concentrations in young adults and non-Western populations. We cross-sectionally examined associations between dietary intake and serum CRP concentrations in young Japanese women. The subjects were 443 female Japanese dietetic students aged 18 to 22 years. Dietary intake was assessed with a validated, self-administered, comprehensive, diet history questionnaire. Serum CRP concentrations were measured by highly sensitive nephelometry. The prevalence of elevated CRP (> or = 1 mg/L) was 5.6%. After adjustment for possible confounding factors including body mass index, a significant inverse association was seen between total n-3 polyunsaturated fatty acid intake and elevated CRP. The multivariate adjusted odds ratios of elevated CRP for women with intake below and above the median (1.1% of energy) were 1.00 and 0.33 (95% confidence interval, 0.13-0.82; P = .02), respectively. Intake of eicosapentaenoic acid + docosahexaenoic acid and alpha-linolenic acid was not associated with elevated CRP concentrations (P = .62 and P = .27, respectively). Vitamin C intake was independently inversely associated with elevated CRP, although the association was nonsignificant (P = .10). No clear associations were observed for other dietary factors examined including total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, total dietary fiber, soluble dietary fiber, insoluble dietary fiber, and magnesium; fruits, vegetables, and fish and shellfish; and dietary glycemic load (P = .27 to P = .99). In conclusion, total n-3 polyunsaturated fatty acid intake showed an independent inverse association with elevated serum CRP concentration in a group of young Japanese women.
关于饮食因素与年轻成年人及非西方人群循环C反应蛋白（CRP）浓度之间的关系，目前所知甚少。我们对年轻日本女性的饮食摄入量与血清CRP浓度之间的关联进行了横断面研究。研究对象为443名年龄在18至22岁之间的日本女性营养学专业学生。通过一份经过验证的、自我填写的、全面的饮食史问卷对饮食摄入量进行评估。采用高敏比浊法测量血清CRP浓度。CRP升高（≥1mg/L）的患病率为5.6%。在对包括体重指数在内的可能混杂因素进行调整后，总n-3多不饱和脂肪酸摄入量与CRP升高之间存在显著的负相关。摄入量低于和高于中位数（能量的1.1%）的女性，CRP升高的多变量调整优势比分别为1.00和0.33（95%置信区间，0.13 - 0.82；P = 0.02）。二十碳五烯酸+二十二碳六烯酸和α-亚麻酸的摄入量与CRP升高浓度无关（P分别为0.62和0.27）。维生素C摄入量与CRP升高独立呈负相关，尽管该关联不显著（P = 0.10）。对于其他所研究的饮食因素，包括总脂肪、饱和脂肪酸、单不饱和脂肪酸、多不饱和脂肪酸、总膳食纤维、可溶性膳食纤维、不溶性膳食纤维和镁；水果、蔬菜以及鱼类和贝类；以及饮食血糖负荷，均未观察到明确的关联（P = 0.27至P = 0.99）。总之，在一组年轻日本女性中，总n-3多不饱和脂肪酸摄入量与血清CRP浓度升高呈独立负相关。
