来自链霉菌属MM23的新型金硫素衍生物——别金硫素。

New aureothin derivative, alloaureothin, from Streptomyces sp. MM23.

作者信息

Ueda Jun-ya, Hashimoto Junko, Nagai Aya, Nakashima Takuji, Komaki Hisayuki, Anzai Kozue, Harayama Shigeaki, Doi Takayuki, Takahashi Takashi, Nagasawa Kazuo, Natsume Tohru, Takagi Motoki, Shin-ya Kazuo

机构信息

Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC).

出版信息

J Antibiot (Tokyo). 2007 May;60(5):321-4. doi: 10.1038/ja.2007.41.

DOI:10.1038/ja.2007.41

PMID:17551211

Abstract

A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 microM.

摘要

从链霉菌属MM23的菌丝体中分离出一种新的带有硝基的聚丙酸金硫素（1）以及一种已知的聚丙酸金硫素（2）。其结构通过光谱数据确定。化合物1对人纤维肉瘤HT1080细胞具有生长抑制作用，IC50值为30微摩尔。