Walsh Michael P
International Consultant, 3105 North Dinwiddie Street, Arlington, VA 22207, USA.
Am J Ind Med. 2007 Nov;50(11):853-60. doi: 10.1002/ajim.20483.
As leaded gasoline is on the verge of being eliminated from all gasoline worldwide another neurotoxin has been put on the market as a lead substitute. Initial concerns regarding the potential adverse health impacts of this additive have emerged and some evidence indicates that its use could damage pollution controls on advance gasoline fueled vehicles. This paper attempts to draw upon the experience with lead in gasoline to see what lessons we should have learned and how these lessons should apply to the use of the new additive, methylcyclopentadienyl manganese tricarbonyl (MMT). Based on the global experience with lead, the question is whether we have sufficient information to conclude that the precautionary principle should apply to the use of MMT; this would require the developer of the additive to demonstrate conclusively that it is safe before it is sold around the world.
由于含铅汽油即将在全球所有汽油中被淘汰,另一种神经毒素作为铅替代品已投放市场。人们已开始关注这种添加剂可能对健康产生的不利影响,并且有证据表明,其使用可能会损害先进汽油燃料汽车的污染控制装置。本文试图借鉴汽油中铅的使用经验,看看我们应该吸取哪些教训,以及这些教训如何应用于新添加剂甲基环戊二烯三羰基锰(MMT)的使用。基于全球对铅的使用经验,问题在于我们是否有足够的信息得出预防性原则应适用于MMT使用的结论;这将要求添加剂的开发者在其在全球销售之前确凿地证明其安全性。