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源自纸皮桦内皮的抗癌二芳基庚烷类糖苷。

Anticancer diarylheptanoid glycosides from the inner bark of Betula papyrifera.

作者信息

Mshvildadze Vakhtang, Legault Jean, Lavoie Serge, Gauthier Charles, Pichette André

机构信息

Laboratoire d'Analyse et de Séparation des Essences Végétales, Département des Sciences Fondamentales, Université du Québec à Chicoutimi, 555 boul. Université, Chicoutimi, Québec, Canada G7H 2B1.

出版信息

Phytochemistry. 2007 Oct;68(20):2531-6. doi: 10.1016/j.phytochem.2007.05.018. Epub 2007 Jun 27.

DOI:10.1016/j.phytochem.2007.05.018
PMID:17599372
Abstract

Phytochemical investigations of the MeOH extract of Betula papyrifera inner bark led to the isolation of ten phenolic compounds of the following types: diarylheptanoid glycosides (1-4), a diarylheptanoid (5), a lignan (6), flavonoids (7-8) and chavicol glycosides (9-10). Among them, the diarylheptanoid glycoside, (S)-1,7-bis-(4-hydroxyphenyl)-heptan-3-one-5-O-alpha-L-arabinofuranosyl-(1-->6)-beta-D-glucopyranoside, papyriferoside A (1), was isolated and its structure was determined on the basis of 1D and 2D NMR, HPLC-MS, as well as high resolution mass spectroscopic data. Platyphylloside (4) exerted the strongest cytotoxic activity of all isolated compounds with IC(50) values ranging from 10.3 to 13.8 microM.

摘要

对纸皮桦内皮甲醇提取物进行植物化学研究，分离出了十种以下类型的酚类化合物：二芳基庚烷糖苷（1-4）、一种二芳基庚烷（5）、一种木脂素（6）、黄酮类化合物（7-8）和查维醇糖苷（9-10）。其中，分离出了二芳基庚烷糖苷（S）-1,7-双-（4-羟基苯基）-庚烷-3-酮-5-O-α-L-阿拉伯呋喃糖基-（1→6）-β-D-吡喃葡萄糖苷，即纸皮桦苷A（1），并根据一维和二维核磁共振、高效液相色谱-质谱以及高分辨率质谱数据确定了其结构。白桦脂醇苷（4）在所有分离出的化合物中表现出最强的细胞毒性活性，其半数抑制浓度（IC50）值在10.3至13.8微摩尔之间。

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