一种来自杨梅树皮的新二氢庚烷类化合物。

A new diaryheptanoid from the bark of Myrica rubra.

作者信息

Wang Ding-Yong, Liu En-Gui

机构信息

Guangdong Pharmaceutical University, College of Pharmacy, Guangdong Pharmaceutical University, Higher Education Mega Center, Guangdong, PR China.

出版信息

Nat Prod Res. 2008 Mar 10;22(4):292-5. doi: 10.1080/14786410701766232.

DOI:10.1080/14786410701766232

PMID:18322844

Abstract

A new diarylheptanoid, (11 xi)-3,5-dimethoxy-11,17-dihydroxy-4,19-diketo-[7,0]-metacyc- lophane, named as rubanol 1, was isolated from the bark of Myrica rubra along with four known compounds (2-5). Their structures were determined by spectroscopic methods including 1D, 2D NMR or comparison with authentic samples. Compound 1 exhibited cytotoxicity against Lun-06, Neu-04, and Bre-04 cell lines with GI50 values of 16.03-32.58 microg mL(-1).

摘要

从杨梅树皮中分离出一种新的二芳基庚烷类化合物，即(11ξ)-3,5-二甲氧基-11,17-二羟基-4,19-二酮-[7,0]-间环环烷，命名为杨梅醇1，同时还分离出四种已知化合物（2-5）。通过一维、二维核磁共振等光谱方法或与标准样品比较确定了它们的结构。化合物1对Lun-06、Neu-04和Bre-04细胞系具有细胞毒性，其GI50值为16.03 - 32.58微克/毫升(-1)。