Bosanac Peter, Kurlender Simone, Stojanovska Lillian, Hallam Karen, Norman Trevor, McGrath Caroline, Burrows Graham, Wesnes Keith, Manktelow Tamsin, Olver James
Department of Psychiatry, University of Melbourne, Austin Hospital, Studley Road, Heidelberg 3084, Melbourne, Australia.
Int J Eat Disord. 2007 Nov;40(7):613-21. doi: 10.1002/eat.20412.
To compare executive, memory and visuospatial functioning of DSM-IV anorexia nervosa (AN), bulimia nervosa (BN), and normal controls (NC).
A comparison of women involving: (i) 16 AN with body mass indices (BMI) < or = 17.5 kg/m(2); (ii) 12 AN with BMI > 18.5 kg/m(2) for at least 3 months; (iii) 13 BN; and (iv) 16 NC participants was performed with groups of similar age and intelligence. Groups were assessed with EDE-12, MADRS, HAMA, Cognitive Drug Research (CDR) battery, and Bechara tasks.
Significant impairments in CDR Power of Attention were present in underweight AN and BN participants. CDR Morse Tapping was significantly impaired in all clinical groups. The BN and weight-recovered AN groups were significantly impaired on CDR immediate word recall. The BN group alone was significantly impaired on CDR delayed word recall.
Attentional impairment is similar in AN and BN. Impaired motor tasks in AN persist after "weight-recovery" and are similar to impairments in BN. BN may be discriminated from AN on word recall.
比较《精神疾病诊断与统计手册》第四版（DSM-IV）中神经性厌食症（AN）、神经性贪食症（BN）和正常对照组（NC）的执行功能、记忆和视觉空间功能。
对女性进行比较，包括：（i）16名体重指数（BMI）≤17.5kg/m²的神经性厌食症患者；（ii）12名BMI＞18.5kg/m²至少3个月的神经性厌食症患者；（iii）13名神经性贪食症患者；以及（iv）16名年龄和智力相似的正常对照参与者。使用进食障碍检查问卷-12项版（EDE-12）、蒙哥马利-艾森伯格抑郁评定量表（MADRS）、汉密尔顿焦虑量表（HAMA）、认知药物研究（CDR）成套测验和贝查拉任务对各组进行评估。
体重过轻的神经性厌食症和神经性贪食症参与者在CDR注意力集中能力方面存在显著损害。所有临床组在CDR莫尔斯敲击测试中均有显著损害。神经性贪食症组和体重恢复的神经性厌食症组在CDR即时单词回忆方面有显著损害。仅神经性贪食症组在CDR延迟单词回忆方面有显著损害。
神经性厌食症和神经性贪食症在注意力损害方面相似。神经性厌食症患者在“体重恢复”后运动任务损害仍然存在，且与神经性贪食症的损害相似。神经性贪食症可通过单词回忆与神经性厌食症相区分。
