Hopkins K L, Maguire C, Best E, Liebana E, Threlfall E J
Laboratory of Enteric Pathogens, Health Protection Agency Centre for Infections, London, United Kingdom.
J Clin Microbiol. 2007 Sep;45(9):3058-61. doi: 10.1128/JCM.00715-07. Epub 2007 Jul 3.
Variable-number tandem repeats (VNTRs) may evolve so rapidly that multiple profiles emerge during an outbreak. A total of 190 isolates from eight Salmonella enterica serovar Typhimurium outbreaks and 15 isolates from seven patients were analyzed by pulsed-field gel electrophoresis and VNTR typing. Small changes in loci were noted; otherwise, the VNTR profiles were stable during the course of the outbreaks.
可变数目串联重复序列(VNTRs)的进化速度可能非常快,以至于在一次疫情暴发期间会出现多种图谱。通过脉冲场凝胶电泳和VNTR分型对来自8起肠炎沙门氏菌鼠伤寒血清型疫情的190株分离株以及来自7名患者的15株分离株进行了分析。观察到基因座有微小变化;否则,在疫情暴发过程中VNTR图谱是稳定的。