Kawakami Yuko, Okada Hiroyuki, Murakami Yasuko, Kawakami Takayo, Ueda Yukiko, Kunii Daisuke, Sakamoto Yachiyo, Shiratori Yasushi, Okita Misako
Department of Human Nutrition, Chugokugakuen University, Okayama 701-0197, Japan.
J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):153-9. doi: 10.3177/jnsv.53.153.
Nutrition may play an important role in the pathogenesis and treatment of ulcerative colitis. Several studies suggest an association between dietary factors and the onset of ulcerative colitis; however, only few studies have examined the relationship between dietary intake and relapse of ulcerative colitis. The aim of this study was to assess the dietary intake and antioxidative capacity of ulcerative colitis patients and to elucidate the efficacy of dietary therapy for ulcerative colitis. Dietary intake, fatty acid composition of phospholipids in plasma and neutrophils, serum fat-soluble vitamin levels, and oxygen radical absorbance capacity were analyzed in 29 ulcerative colitis patients (7 males and 22 females), who were treated at the Department of Gastroenterology, Okayama University Hospital. Total fat intake, fat energy ratio and linoleic acid intake were significantly lower, while protein and carbohydrate intakes were significantly higher, in the patients than age- and sex-matched controls. In the neutrophil phospholipids of ulcerative colitis patients, significantly higher levels of linoleic aicd and arachidonic acid and a lower level of eicosapentaenoic acid were observed. The concentrations of serum retinol and beta-carotene but not alpha-tocopherol were significantly lower and serum oxygen radical absorbance capacity was also lower than in the controls. Significant correlations between serum oxygen radical absorbance capacity and retinol (r = 0.567, p = 0.0031), alpha-tocopherol (r = 0.560, p = 0.0036) and beta-carotene (r = 0.440, p = 0.0279) concentrations were observed in the ulcerative colitis patients. A diet restricting the intake of linoleic acid and supplemented with eicosapentaenoic acid and antioxidative vitamins may be recommendable for the nutritional management of ulcerative colitis patients.
营养可能在溃疡性结肠炎的发病机制和治疗中发挥重要作用。多项研究表明饮食因素与溃疡性结肠炎的发病之间存在关联；然而，仅有少数研究探讨了饮食摄入与溃疡性结肠炎复发之间的关系。本研究的目的是评估溃疡性结肠炎患者的饮食摄入和抗氧化能力，并阐明饮食疗法对溃疡性结肠炎的疗效。对冈山大学医院胃肠病科治疗的29例溃疡性结肠炎患者（7例男性和22例女性）的饮食摄入、血浆和中性粒细胞中磷脂的脂肪酸组成、血清脂溶性维生素水平以及氧自由基吸收能力进行了分析。与年龄和性别匹配的对照组相比，患者的总脂肪摄入量、脂肪能量比和亚油酸摄入量显著降低，而蛋白质和碳水化合物摄入量显著升高。在溃疡性结肠炎患者的中性粒细胞磷脂中，观察到亚油酸和花生四烯酸水平显著升高，而二十碳五烯酸水平降低。血清视黄醇和β-胡萝卜素的浓度显著低于对照组，但α-生育酚的浓度无显著差异，且血清氧自由基吸收能力也低于对照组。在溃疡性结肠炎患者中，观察到血清氧自由基吸收能力与视黄醇（r = 0.567，p = 0.0031）、α-生育酚（r = 0.560，p = 0.0036）和β-胡萝卜素（r = 0.440，p = 0.0279）浓度之间存在显著相关性。对于溃疡性结肠炎患者的营养管理，限制亚油酸摄入并补充二十碳五烯酸和抗氧化维生素的饮食可能是可取的。
