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1
The las enzymes control pyruvate metabolism in Lactococcus lactis during growth on maltose.乳酸乳球菌在以麦芽糖为生长底物时，las酶控制丙酮酸代谢。
J Bacteriol. 2007 Sep;189(18):6727-30. doi: 10.1128/JB.00902-07. Epub 2007 Jul 6.
2
Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis.作为理解乳酸乳球菌中乳糖操纵子形成工具的控制分析
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3
Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA.乳酸乳球菌中糖酵解las操纵子的转录激活和gal操纵子的分解代谢物阻遏由分解代谢物控制蛋白CcpA介导。
Mol Microbiol. 1998 Nov;30(4):789-98. doi: 10.1046/j.1365-2958.1998.01111.x.
4
Twofold reduction of phosphofructokinase activity in Lactococcus lactis results in strong decreases in growth rate and in glycolytic flux.乳酸乳球菌中磷酸果糖激酶活性降低两倍会导致生长速率和糖酵解通量大幅下降。
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Regulation of pyruvate metabolism in Lactococcus lactis depends on the imbalance between catabolism and anabolism.乳酸乳球菌中丙酮酸代谢的调控取决于分解代谢和合成代谢之间的失衡。
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6
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Identification of a novel operon in Lactococcus lactis encoding three enzymes for lactic acid synthesis: phosphofructokinase, pyruvate kinase, and lactate dehydrogenase.在乳酸乳球菌中鉴定出一个新的操纵子，其编码用于乳酸合成的三种酶：磷酸果糖激酶、丙酮酸激酶和乳酸脱氢酶。
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[Effect of 6-phosphofructokinase gene-pfk overexpression on nisin production in Lactococcus lactis N8].[6-磷酸果糖激酶基因-pfk过表达对乳酸乳球菌N8产乳链菌肽的影响]
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Improved medium for lactic streptococci and their bacteriophages.用于乳酸链球菌及其噬菌体的改良培养基。
Appl Microbiol. 1975 Jun;29(6):807-13. doi: 10.1128/am.29.6.807-813.1975.
2
beta-Glucose-1-Phosphate, a Possible Mediator for Polysaccharide Formation in Maltose-Assimilating Lactococcus lactis.β-葡萄糖-1-磷酸，麦芽糖同化乳球菌多糖形成的可能介质。
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3
Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis.作为理解乳酸乳球菌中乳糖操纵子形成工具的控制分析
FEBS J. 2005 May;272(9):2292-303. doi: 10.1111/j.1742-4658.2005.04656.x.
4
Reappraisal of the regulation of lactococcal L-lactate dehydrogenase.乳酸乳球菌L-乳酸脱氢酶调控的重新评估
Appl Environ Microbiol. 2004 Mar;70(3):1843-6. doi: 10.1128/AEM.70.3.1843-1846.2004.
5
FRUCTOSE-1,6-DIPHOSPHATE REQUIREMENT OF STREPTOCOCCAL LACTIC DEHYDROGENASES.链球菌乳酸脱氢酶对1,6-二磷酸果糖的需求
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Glyceraldehyde-3-phosphate dehydrogenase has no control over glycolytic flux in Lactococcus lactis MG1363.甘油醛-3-磷酸脱氢酶对乳酸乳球菌MG1363中的糖酵解通量没有调控作用。
J Bacteriol. 2003 Mar;185(5):1564-71. doi: 10.1128/JB.185.5.1564-1571.2003.
7
Expression of genes encoding F(1)-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis.编码F(1)-ATP酶的基因表达导致乳酸乳球菌中糖酵解与生物量产生解偶联。
Appl Environ Microbiol. 2002 Sep;68(9):4274-82. doi: 10.1128/AEM.68.9.4274-4282.2002.
8
Modulation of gene expression made easy.基因表达调控变得轻松。
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9
The level of pyruvate-formate lyase controls the shift from homolactic to mixed-acid product formation in Lactococcus lactis.丙酮酸甲酸裂解酶的水平控制乳酸乳球菌中从同型乳酸产物形成到混合酸产物形成的转变。
Appl Microbiol Biotechnol. 2002 Mar;58(3):338-44. doi: 10.1007/s00253-001-0892-5. Epub 2001 Dec 8.
10
Lactate dehydrogenase has no control on lactate production but has a strong negative control on formate production in Lactococcus lactis.乳酸脱氢酶对乳酸乳球菌中乳酸的产生没有调控作用，但对甲酸的产生有很强的负调控作用。
Eur J Biochem. 2001 Dec;268(24):6379-89. doi: 10.1046/j.0014-2956.2001.02599.x.

乳酸乳球菌在以麦芽糖为生长底物时，las酶控制丙酮酸代谢。

The las enzymes control pyruvate metabolism in Lactococcus lactis during growth on maltose.

作者信息

Solem Christian, Koebmann Brian, Yang Fen, Jensen Peter R

机构信息

Systems Microbiology, BioCentrum-DTU, Technical University of Denmark, Building 301, DK-2800 Kgs. Lyngby, Denmark.

出版信息

J Bacteriol. 2007 Sep;189(18):6727-30. doi: 10.1128/JB.00902-07. Epub 2007 Jul 6.

DOI:10.1128/JB.00902-07
PMID:17616595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2045170/
Abstract

The fermentation pattern of Lactococcus lactis with altered activities of the las enzymes was examined on maltose. The wild type converted 65% of the maltose to mixed acids. An increase in phosphofructokinase or lactate dehydrogenase expression shifted the fermentation towards homolactic fermentation, and with a high level of expression of the las operon the fermentation was homolactic.

摘要

研究了乳酸乳球菌中las酶活性改变后在麦芽糖上的发酵模式。野生型将65%的麦芽糖转化为混合酸。磷酸果糖激酶或乳酸脱氢酶表达的增加使发酵向同型乳酸发酵转变，并且在las操纵子高表达水平下发酵为同型乳酸发酵。