Ramanath H S, Chua C K, Leong K F, Shah K D
Singapore Institute of Manufacturing Technology, Singapore.
J Mater Sci Mater Med. 2008 Jul;19(7):2541-50. doi: 10.1007/s10856-007-3203-6. Epub 2007 Jul 10.
Fused deposition modelling (FDM) is an extrusion based Rapid prototyping (RP) technique which can be used to fabricate tissue engineering scaffolds. The present work focuses on the study of the melt flow behaviour (MFB) of Poly-epsilon-caprolactone (PCL) as a representative biomaterial, on the FDM. The MFB significantly affects the quality of the scaffold which depends not only on the pressure gradient, its velocity, and the temperature gradients but also physical properties like the melt temperature and rheology. The MFB is studied using two methods: mathematical modelling and finite element analysis (FEA) using Ansys(R). The MFB is studied using accurate channel geometry by varying filament velocity at the entry and by varying nozzle diameters and angles at the exit. The comparative results of both mathematical modelling and FEA suggest that the pressure drop and the velocities of the melt flow depend on the flow channel parameters. One inference of particular interest is the temperature gradient of the PCL melt, which shows that it liquefies within 35% of the channel length. These results are invaluable to better understand the MFB of biomaterials that affects the quality of the scaffold built via FDM and can also be used to predict the MFB of other biomaterials.
熔融沉积建模(FDM)是一种基于挤出的快速成型(RP)技术,可用于制造组织工程支架。目前的工作重点是研究聚己内酯(PCL)作为代表性生物材料在FDM上的熔体流动行为(MFB)。MFB显著影响支架的质量,支架质量不仅取决于压力梯度、其速度和温度梯度,还取决于诸如熔体温度和流变学等物理性质。使用两种方法研究MFB:数学建模和使用Ansys(R)的有限元分析(FEA)。通过改变入口处的长丝速度以及出口处的喷嘴直径和角度,使用精确的通道几何形状来研究MFB。数学建模和FEA的比较结果表明,熔体流动的压降和速度取决于流动通道参数。一个特别有趣的推断是PCL熔体的温度梯度,它表明它在通道长度的35%内液化。这些结果对于更好地理解影响通过FDM构建的支架质量的生物材料的MFB非常宝贵,也可用于预测其他生物材料的MFB。