Sutar Prashant B, Mishra Rakesh K, Pal Kunal, Banthia Ajit K
Materials Science Centre, Indian Institute of Technology, Kharagpur, 721302, India.
J Mater Sci Mater Med. 2008 Jun;19(6):2247-53. doi: 10.1007/s10856-007-3162-y. Epub 2007 Jul 10.
In the present study an attempt was made to graft polyacrylamide on pectin. The grafted polymer was characterized by FTIR spectroscopy, differential scanning calorimetry and X-ray diffraction. Rheological property of pectin solution was compared with the product solution. The grafted polymer was cross-linked with varying amount of glutaraldehyde. The swelling properties of the cross-linked product were also studied. The salicylic acid, an antipyretic drug, was incorporated in the cross-linked gel as a model drug and the drug release studies were done in a modified Franz's diffusion cell. The effect of cross-linking density on the release property of salicylic acid was studied through the cross-linked product. The product showed better film forming property and gelling property than pectin. The comparative rheological properties of pectin and grafted copolymer indicated change in the property of the product. FTIR studies indicated incorporation of amide group. Differential scanning calorimetry and XRD suggested formation of a new polymer. Swelling study indicated pH dependent swelling of the cross-linked hydrogel. Salicylic acid release indicated pH dependent release from the hydrogel.
在本研究中，尝试将聚丙烯酰胺接枝到果胶上。通过傅里叶变换红外光谱、差示扫描量热法和X射线衍射对接枝聚合物进行了表征。将果胶溶液的流变特性与产物溶液进行了比较。使接枝聚合物与不同量的戊二醛交联。还研究了交联产物的溶胀特性。将解热药物水杨酸作为模型药物掺入交联凝胶中，并在改良的弗兰兹扩散池中进行药物释放研究。通过交联产物研究了交联密度对水杨酸释放特性的影响。该产物显示出比果胶更好的成膜性和胶凝性。果胶和接枝共聚物的比较流变特性表明产物的性质发生了变化。傅里叶变换红外光谱研究表明酰胺基团的引入。差示扫描量热法和X射线衍射表明形成了一种新聚合物。溶胀研究表明交联水凝胶的溶胀依赖于pH值。水杨酸释放表明其从水凝胶中的释放依赖于pH值。
