用一种农用唑类药物治疗具有临床相关性的植物致病真菌会导致对医用唑类药物产生交叉耐药性，并增强卡泊芬净的疗效。
Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy.
作者信息
Serfling Albrecht, Wohlrab Johannes, Deising Holger B
机构信息
Faculty of Agriculture, Institute of Agricultural and Nutritional Sciences, Phytopathology and Plant Protection, Martin Luther University Halle-Wittenberg, D-06099, Halle (Saale), Germany.
出版信息
Antimicrob Agents Chemother. 2007 Oct;51(10):3672-6. doi: 10.1128/AAC.00654-07. Epub 2007 Jul 9.
Abstract
Azoles are extensively applied in agriculture and medicine, and a relationship between the development of azole resistance in agriculture and the development of azole resistance in clinical practice may exist. The maize pathogen Colletotrichum graminicola, causing cutaneous mycosis and keratitis, has been used to investigate the acquisition of resistance to an agricultural azole and the resulting cross-resistance to various medical antifungal agents. Azole-adapted strains were less sensitive to all azoles tested but showed increased sensitivity to caspofungin, amphotericin B, and nystatin. Viability staining and infection assays with excised human skin confirmed these data.
摘要
唑类广泛应用于农业和医学领域，农业中唑类抗性的发展与临床实践中唑类抗性的发展之间可能存在关联。玉米病原体禾谷炭疽菌可导致皮肤真菌病和角膜炎，已被用于研究对农业用唑类抗性的获得以及由此产生的对各种医用抗真菌剂的交叉抗性。适应唑类的菌株对所有测试的唑类药物敏感性降低，但对卡泊芬净、两性霉素B和制霉菌素的敏感性增加。用切除的人体皮肤进行的活力染色和感染试验证实了这些数据。
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