Edwards Kate M, Ziegler Michael G, Mills Paul J
Department of Psychiatry, UCSD Medical Center, University of California, San Diego, La Jolla, California 92093-0804, USA.
J Hypertens. 2007 Aug;25(8):1533-42. doi: 10.1097/HJH.0b013e328165ca67.
Hypertension is associated with an increased risk of stroke and atherosclerosis. In addition to elevated blood pressure, hypertension is characterized by neuroendocrine and immune activation, including elevated levels of C-reactive protein, inflammatory cytokines, and soluble adhesion molecules, which are predictive of morbidity and mortality outcomes. Pharmacological treatment for hypertension reduces blood pressure, but has limited effectiveness in reducing the accompanying inflammation and its associated morbidity and mortality. Exercise and diet interventions regularly show reductions in blood pressure in hypertensive individuals. Similar interventions in other populations show reductions in many inflammatory markers, but these effects have not been routinely examined in hypertensive individuals. The mechanisms through which exercise might exert an anti-inflammatory action include the sympathetic nervous system, the hypothalamic-pituitary-adrenal axis, as well as direct effects of blood pressure. Here, exercise is promoted as a potentially effective treatment for both the elevated blood pressure and chronic inflammation found in hypertension.
高血压与中风和动脉粥样硬化风险增加相关。除血压升高外，高血压的特征还包括神经内分泌和免疫激活，其中包括C反应蛋白、炎性细胞因子和可溶性黏附分子水平升高，这些都可预测发病和死亡结局。高血压的药物治疗可降低血压，但在减轻伴随的炎症及其相关的发病和死亡方面效果有限。运动和饮食干预通常可使高血压个体的血压降低。在其他人群中进行的类似干预可使多种炎症标志物水平降低，但尚未对高血压个体进行常规检查。运动可能发挥抗炎作用的机制包括交感神经系统、下丘脑-垂体-肾上腺轴以及血压的直接影响。在此，运动被认为是治疗高血压中血压升高和慢性炎症的一种潜在有效方法。
