Cetin K, Johnson K L, Ehde D M, Kuehn C M, Amtmann D, Kraft G H
Department of Rehabilitation Medicine, School of Medicine, University of Washington, Box 356490, Seattle, WA 98195, USA.
Mult Scler. 2007 Sep;13(8):1046-53. doi: 10.1177/1352458507077864. Epub 2007 Jul 10.
Depressive symptoms and disorders among individuals with multiple sclerosis (MS) are more common when compared to other chronic illnesses and the general population, but relatively little is known about the use of antidepressant medication in this population. In this cross-sectional study of 542 community-dwelling adults with MS, we examined the prevalence of antidepressant use and employed multivariate logistic regression modeling to identify factors significantly associated with antidepressant use. Thirty-five percent of the sample reported currently using at least one antidepressant medication. Gender, marital status, insurance status, fatigue, and use of disease modifying therapies were all significantly associated with antidepressant use. Just over half of the sample endorsed a clinically significant level of depressive symptoms, and the majority of this group was not currently taking an antidepressant. Conversely, 41% of those with depressive symptoms reported taking at least one antidepressant medication. More research is needed to better understand why people with MS and depressive symptoms use or do not use antidepressant medications and to further explore the possibility of an under-treatment of depressive disorder in this population. Rigorous studies testing the feasibility, acceptability, and efficacy of currently available therapies for depression in the MS population should also be conducted.
与其他慢性疾病患者及普通人群相比，多发性硬化症（MS）患者中抑郁症状及障碍更为常见，但对于该人群抗抑郁药物的使用情况却知之甚少。在这项针对542名社区居住的成年MS患者的横断面研究中，我们调查了抗抑郁药物的使用 prevalence，并采用多变量逻辑回归模型来确定与抗抑郁药物使用显著相关的因素。35%的样本报告目前正在使用至少一种抗抑郁药物。性别、婚姻状况、保险状况、疲劳以及疾病修饰疗法的使用均与抗抑郁药物的使用显著相关。略超过一半的样本认可临床上显著水平的抑郁症状，且该组中的大多数人目前未服用抗抑郁药物。相反，41%有抑郁症状的人报告正在服用至少一种抗抑郁药物。需要更多研究来更好地理解为什么有MS和抑郁症状的人使用或不使用抗抑郁药物，并进一步探索该人群中抑郁症治疗不足的可能性。还应进行严格的研究，测试目前可用的MS人群抑郁症治疗方法的可行性、可接受性和疗效。
