Feldschuh Joseph, Katz Stuart
Daxor Corporation, New York, NY, USA.
Am J Med Sci. 2007 Jul;334(1):41-6. doi: 10.1097/MAJ.0b013e318063c707.
Accurate individual norms are required for blood volume measurement to be useful in a clinical setting. The primary physiological determinant of normal blood volume is body composition. Norms have been developed based on weight and body surface area, but these have systematic errors arising from variations in body composition or body size. The only norm that specifically estimates body composition uses deviation from ideal weight. A clinically useful norm must also include a normal range that is sufficiently sensitive and specific. The ultimate test of a norm's effectiveness is how it relates to known physiological factors or outcomes in a clinical or research setting. When tested in relation to outcome results from previously published clinical studies, norms utilizing deviation from ideal weight provide the most accurate categorization of blood volume status.
在临床环境中，要使血容量测量有用，就需要准确的个体标准。正常血容量的主要生理决定因素是身体组成。已经根据体重和体表面积制定了标准，但这些标准因身体组成或体型的变化而存在系统误差。唯一专门估计身体组成的标准是使用与理想体重的偏差。临床上有用的标准还必须包括一个足够敏感和特异的正常范围。一个标准有效性的最终检验是它在临床或研究环境中与已知生理因素或结果的关联程度。当根据先前发表的临床研究的结果进行测试时，利用与理想体重偏差的标准能提供最准确的血容量状态分类。
