Magkos Faidon, Tsekouras Yannis, Kavouras Stavros A, Mittendorfer Bettina, Sidossis Labros S
Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
Clin Sci (Lond). 2008 Jan;114(1):59-64. doi: 10.1042/CS20070134.
A single bout of moderate-intensity exercise increases whole-body insulin sensitivity for 12-48 h post-exercise; however, the relationship between exercise energy expenditure and the improvement in insulin sensitivity is not known. We hypothesized that the exercise-induced increase in whole-body insulin sensitivity, assessed with HOMA(IR) (homoeostasis model assessment of insulin resistance), is directly related to the energy expended during exercise. We studied 30 recreationally active non-obese men (age, 27+/-5 years; body mass index, 24+/-2 kg/m(2)) in the post-absorptive state on two separate occasions: once after exercising at 60% of VO(22peak) (peak oxygen consumption) for 30-120 min on the preceding afternoon (expending a total of 1.28-5.76 MJ) and once after an equivalent period of rest. Blood samples were obtained the following morning. Exercise-induced changes in HOMA(IR) were curvilinearly related to exercise energy expenditure (r=-0.666, P=0.001) with a threshold of approx. 3.77 MJ (900 kcal) for improvements in HOMA(IR) to be manifested. In particular, HOMA(IR) was reduced by 32+/-24% (P=0.003) in subjects who expended more than 3.77 MJ during exercise, but did not change for those who expended fewer than 3.77 MJ (-2+/-21%; P=0.301). Furthermore, the magnitude of change in HOMA(IR) after exercise was directly associated with baseline (i.e. resting) HOMA(IR) (r=-0.508, P=0.004); this relationship persisted in multivariate analysis. We conclude that improved whole-body insulin resistance after a single bout of exercise is curvilinearly related to exercise energy expenditure, and requires unfeasible amounts of exercise for most sedentary individuals.
单次中等强度运动可使运动后12 - 48小时内全身胰岛素敏感性增加；然而，运动能量消耗与胰岛素敏感性改善之间的关系尚不清楚。我们假设，通过HOMA(IR)（胰岛素抵抗稳态模型评估）评估的运动诱导的全身胰岛素敏感性增加与运动期间消耗的能量直接相关。我们在两个不同的场合研究了30名有休闲运动习惯的非肥胖男性（年龄，27±5岁；体重指数，24±2 kg/m²），均处于空腹状态：一次是在前一天下午以60%的VO₂峰值（最大摄氧量）运动30 - 120分钟后（总共消耗1.28 - 5.76兆焦耳），另一次是在同等时长的休息后。次日早晨采集血样。运动诱导的HOMA(IR)变化与运动能量消耗呈曲线相关（r = -0.666，P = 0.001），HOMA(IR)改善的阈值约为3.77兆焦耳（900千卡）。特别是，运动期间消耗超过3.77兆焦耳的受试者，其HOMA(IR)降低了32±24%（P = 0.003），而消耗少于3.77兆焦耳的受试者HOMA(IR)没有变化（-2±21%；P = 0.301）。此外，运动后HOMA(IR)的变化幅度与基线（即静息）HOMA(IR)直接相关（r = -0.508，P = 0.004）；这种关系在多变量分析中持续存在。我们得出结论，单次运动后全身胰岛素抵抗的改善与运动能量消耗呈曲线相关，且对大多数久坐不动的个体而言，需要进行不切实际的运动量。
