来自灵芝的三种具有前所未有的Δ(16, 17)双键的新羊毛甾烷型三萜的结构解析及完整核磁共振光谱归属

Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Delta(16, 17) double bond from Ganoderma lucidum.

作者信息

Guan Shu-Hong, Yang Min, Wang Xiao-Ming, Xia Jia-Meng, Zhang Zhi-Ming, Liu Xuan, Guo De-An

机构信息

Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Zhangjiang Hitech Park, Guoshoujing Road #199, Shanghai 201203, P.R. China.

出版信息

Magn Reson Chem. 2007 Sep;45(9):789-91. doi: 10.1002/mrc.2046.

DOI:10.1002/mrc.2046

PMID:17640004

Abstract

Three new lanostanoid triterpenes named 3beta,7beta-di- hydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid (1), 3beta,7beta-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 12beta-acetoxy-3beta,7beta-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid (3) were isolated from the fruit bodies of Ganoderma lucidum. They all show a Delta(16, 17) double bond unprecedented in such types of lanostanoid triterpenes possessing the side chain at C-17. The complete NMR assignments for these compounds were carried out using (1)H, (13)C, DEPT, COSY, HSQC, HMBC, and ROESY NMR experiments.

摘要

从灵芝子实体中分离出三种新的羊毛甾烷型三萜，分别命名为3β,7β - 二羟基 - 11,15,23 - 三氧代 - 羊毛甾 - 8,16 - 二烯 - 26 - 酸（1）、3β,7β - 二羟基 - 11,15,23 - 三氧代 - 羊毛甾 - 8,16 - 二烯 - 26 - 酸甲酯（2）和12β - 乙酰氧基 - 3β,7β - 二羟基 - 11,15,23 - 三氧代 - 羊毛甾 - 8,16 - 二烯 - 26 - 酸（3）。它们在具有C - 17侧链的此类羊毛甾烷型三萜中均显示出前所未有的Δ(16, 17)双键。使用¹H、¹³C、DEPT、COSY、HSQC、HMBC和ROESY NMR实验对这些化合物进行了完整的NMR归属。