Meyer M, Speight P, Bown S G
Department of Surgery, University College, University of London, UK.
Br J Cancer. 1991 Dec;64(6):1093-7. doi: 10.1038/bjc.1991.470.
Photodynamic therapy (PDT) is an anti-cancer treatment which involves the systemic administration of a photosensitising drug which is preferentially absorbed by tumour tissue. Relatively little drug should be absorbed by the surrounding normal tissues. Tumour destruction is achieved when the tumour is illuminated with light of a wavelength which activates the photosensitising drug thereby inducing a cytotoxic reaction. However studies in many tissues have shown that the hoped for tumour selectivity is rarely achieved. Using the rabbit mandible and gingiva as our models we have studied the effects of various doses of PDT on the tissues of the oral cavity, namely mucosa, bone, muscle and salivary gland. The photosensitiser used was di-sulphonated aluminium phthalocyanine. Results show that whereas bone is extremely resistant to PDT the other tissues are vulnerable to it. In the case of muscle and salivary gland this susceptibility is very much dose related. In salivary tissue necrotising sialometaplasia was observed in areas of the gland adjacent to those that had undergone necrosis. All tissues were noted to heal or regenerate well following PDT injury.
光动力疗法（PDT）是一种抗癌治疗方法，它涉及系统性给予一种光敏药物，这种药物会优先被肿瘤组织吸收。周围正常组织应较少吸收该药物。当用能激活光敏药物的波长的光照射肿瘤时，会引发细胞毒性反应，从而实现肿瘤破坏。然而，许多组织的研究表明，很少能实现所期望的肿瘤选择性。我们以兔下颌骨和牙龈为模型，研究了不同剂量的光动力疗法对口腔组织（即黏膜、骨骼、肌肉和唾液腺）的影响。所用的光敏剂是二磺化铝酞菁。结果表明，骨骼对光动力疗法具有极强的抗性，而其他组织则易受其影响。对于肌肉和唾液腺，这种易感性与剂量密切相关。在唾液组织中，在腺体中与发生坏死区域相邻的部位观察到了坏死性涎腺化生。所有组织在光动力疗法损伤后均能良好愈合或再生。
