Lappin Julia M, Morgan Kevin D, Morgan Craig, Dazzan Paola, Reichenberg Abraham, Zanelli Jolanta W, Fearon Paul, Jones Peter B, Lloyd Tuhina, Tarrant Jane, Farrant Annette, Leff Julian, Murray Robin M
Kings College Hospital Institute of Psychiatry, Division of Psychological Medicine, PO63, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.
Schizophr Res. 2007 Sep;95(1-3):103-10. doi: 10.1016/j.schres.2007.05.037. Epub 2007 Jul 20.
We investigated whether duration of untreated psychosis (DUP) prior to first presentation was associated with cognitive function in first episode psychosis (FEP) subjects. We predicted that longer DUP would be associated with greater neurocognitive impairment.
180 subjects with schizophrenia (and 93 subjects with Other Psychoses) performed a neurocognitive battery assessing IQ, verbal learning, working memory, visual learning and speed of processing. DUP was defined as the number of days between first onset of psychotic symptoms and first contact with psychiatric services.
Longer DUP was associated with impaired performance in verbal IQ (p=0.04), verbal learning (p=0.02), and verbal working memory (p=0.04) in FEP subjects with schizophrenia. These associations remained significant for verbal IQ when scores were corrected for age, gender, educational level and ethnicity.
Longer DUP is associated with poorer neurocognitive ability in schizophrenia subjects at time of first presentation. Since this was a cross-sectional study we can not tell whether longer DUP was a cause or a consequence of the poorer performance.
我们研究了首次就诊前未治疗精神病的持续时间（DUP）是否与首发精神病（FEP）患者的认知功能相关。我们预测，DUP越长，神经认知损害越严重。
180名精神分裂症患者（以及93名患有其他精神病的患者）进行了一项神经认知测试，评估智商、言语学习、工作记忆、视觉学习和处理速度。DUP定义为精神病症状首次发作与首次接触精神科服务之间的天数。
在患有精神分裂症的FEP患者中，较长的DUP与言语智商（p = 0.04）、言语学习（p = 0.02）和言语工作记忆（p = 0.04）表现受损相关。在对年龄、性别、教育水平和种族进行分数校正后，这些关联对言语智商仍然显著。
在首次就诊时，较长的DUP与精神分裂症患者较差的神经认知能力相关。由于这是一项横断面研究，我们无法确定较长的DUP是表现较差的原因还是结果。
