Kinlen L J, Rogot E
CRC Cancer Epidemiology Unit, University of Edinburgh.
BMJ. 1988 Sep 10;297(6649):657-9. doi: 10.1136/bmj.297.6649.657.
The relation between leukaemia and smoking habits was examined in data from the veterans' smoking study, a prospective study of mortality among 248,000 United States veterans, of whom 723 died of leukaemia during 1954-69. A significant increase in mortality from leukaemia among cigarette smokers (relative risk 1.53) was found, together with a dose-response relation with amount smoked (trend p less than 0.001). The relation was strongest (relative risk 1.72) for monocytic and chronic and unspecified myeloid leukaemias (ICD (7th revision) codes 204.1 and 204.2). For these leukaemias the increase was almost twofold (relative risk 1.93) among current smokers of over 20 cigarettes daily. Ex-cigarette smokers also showed an increase of leukaemia (relative risk 1.39; p less than 0.001). These findings are consistent with other studies and relevant to the interpretation of minor increases of leukaemia both in population and in individual based studies. If causal they also imply that smoking is responsible for many more deaths from leukaemia in adults than all other known causes combined.
在退伍军人吸烟研究的数据中，对白血病与吸烟习惯之间的关系进行了研究。该研究是一项对248,000名美国退伍军人死亡率的前瞻性研究，其中723人在1954年至1969年期间死于白血病。研究发现，吸烟者中白血病死亡率显著增加（相对风险1.53），并且与吸烟量存在剂量反应关系（趋势p小于0.001）。单核细胞性白血病、慢性髓性白血病及未分类的髓性白血病（国际疾病分类（第7版）编码204.1和204.2）的这种关系最为明显（相对风险1.72）。对于这些白血病，每日吸烟超过20支的现吸烟者中，发病率几乎增加了一倍（相对风险1.93）。既往吸烟者的白血病发病率也有所增加（相对风险1.39；p小于0.001）。这些发现与其他研究一致，并且与基于人群和个体研究中白血病轻度增加的解释相关。如果存在因果关系，这也意味着在成年人中，吸烟导致的白血病死亡人数比所有其他已知原因导致的死亡人数总和还要多。
