Ashkenazi J, Dicker D, Feldberg D, Goldman J A
Sherman Fertility Institute, Department Obstetrics-Gynecology, Golda Meir Medical Center, Petah-Tikva, Israel.
Eur J Obstet Gynecol Reprod Biol. 1991 Nov 26;42(2):115-7. doi: 10.1016/0028-2243(91)90171-g.
Frozen thawed semen has been associated with reduced semen quality and as a result diminished pregnancy rates. In vitro fertilization (IVF) can supply the true measure of the functional fertilizing capacity of fresh versus frozen-thawed semen. One hundred and six patients in an IVF program who underwent donor insemination were divided into two groups. Group I included 51 women in whom initial insemination with donor fresh or frozen semen was performed. They were compared to 65 group II women in whom late insemination with donor fresh or frozen semen was performed after initial insemination with husband semen had failed to fertilize the eggs. There was no statistically significant difference between groups I and II on initial insemination; however, statistically significant difference in fertilization (P less than 0.006) and pregnancy rates (P less than 0.001) between the two groups were achieved when late insemination was carried out. Consequently, we prefer initial insemination with frozen-thawed donor semen in cases indicated.
冻融精液与精液质量下降有关，从而导致妊娠率降低。体外受精（IVF）可以提供新鲜精液与冻融精液功能受精能力的真实衡量标准。在一个体外受精项目中，106名接受供体授精的患者被分为两组。第一组包括51名女性，她们最初接受了供体新鲜或冷冻精液的授精。将她们与第二组的65名女性进行比较，第二组女性在丈夫精液初次授精未能使卵子受精后，接受了供体新鲜或冷冻精液的晚期授精。两组在初次授精时没有统计学上的显著差异；然而，当进行晚期授精时，两组在受精率（P小于0.006）和妊娠率（P小于0.001）方面存在统计学上的显著差异。因此，在有指征的情况下，我们更倾向于使用冻融供体精液进行初次授精。
