Pitkala K H, Strandberg T E, Finne Soveri U H, Ouwehand A C, Poussa T, Salminen S
K.H. Pitkala, Helsinki University Hospital, Department of Medicine, Clinics of General Internal Medicine and Geriatrics, Po Box 340, Fin-00029 HUS, Finland.
J Nutr Health Aging. 2007 Jul-Aug;11(4):305-11.
To assess how fermented oat drink with two selected Bifidobacterium longum strains influences bowel movements among elderly nursing home residents.
A randomized, double-blind, placebo-controlled trial.
12 wards in two nursing homes in Finland.
209 residents.
Wards were randomized to receive daily a fermented oat drink with 1) 109 CFU/day Bifidobacterium longum strains or 2) 109 CFU/day Bifidobacterium lactis Bb12 or 3) without viable bacteria (placebo) for 7 months.
Regularity of bowel movements (no movements or functioning) and consistency of stools (normal, soft or diarrhoea) were recorded for each resident on a daily basis.
The fermented oat drinks were well taken by the subjects, compliance being 85%. The groups receiving active products had more frequent bowel movements than did the placebo group (B. longum group normal functioning 28.5% of follow-up days, B.lactis group 26.9%, and placebo group 20.0%, respectively). The differences between the B. longum and the placebo group (mean 7.1, 95% CI 2.3 - 11.9, p=0.004) and between the B.lactis group and the placebo (mean 6.7, 95% CI 2.5 - 10.9, p = 0.002) were significant even when diarrhoea and constipation in the 3 months prior to the study were used as covariates.
It is possible to normalize bowel movements in frail nursing home.
评估含有两种选定的长双歧杆菌菌株的发酵燕麦饮品对老年疗养院居民排便的影响。
一项随机、双盲、安慰剂对照试验。
芬兰两家疗养院的12个病房。
209名居民。
病房被随机分配，分别每日接受以下饮品，为期7个月：1）含有10⁹CFU/天的长双歧杆菌菌株的发酵燕麦饮品；2）含有10⁹CFU/天的乳酸双歧杆菌Bb12的发酵燕麦饮品；3）不含活菌的饮品（安慰剂）。
每天记录每位居民的排便规律（无排便或正常排便）和粪便稠度（正常、软便或腹泻）。
受试者对发酵燕麦饮品的接受度良好，依从率为85%。接受活性产品的组比安慰剂组排便更频繁（长双歧杆菌组在随访天数中有28.5%排便正常，乳酸双歧杆菌组为26.9%，安慰剂组为20.0%）。即使将研究前3个月的腹泻和便秘情况作为协变量，长双歧杆菌组与安慰剂组之间（均值7.1，95%可信区间2.3 - 11.9，p = 0.004）以及乳酸双歧杆菌组与安慰剂组之间（均值6.7，95%可信区间2.5 - 10.9，p = 0.002）的差异仍具有显著性。
在体弱的疗养院居民中使排便正常化是有可能的。
