经验性治疗选择对甲氧西林敏感金黄色葡萄球菌所致感染性心内膜炎静脉吸毒者预后的影响。
Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus.
作者信息
Lodise Thomas P, McKinnon Peggy S, Levine Donald P, Rybak Michael J
机构信息
Albany College of Pharmacy, Albany, NY 12208-3492, USA.
出版信息
Antimicrob Agents Chemother. 2007 Oct;51(10):3731-3. doi: 10.1128/AAC.00101-07. Epub 2007 Jul 30.
Abstract
This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.
摘要
本研究比较了静脉吸毒且由甲氧西林敏感金黄色葡萄球菌引起感染性心内膜炎的患者使用β-内酰胺类药物和万古霉素的情况。接受万古霉素治疗的患者有更高的感染相关死亡率，即便在培养结果出来后换用β-内酰胺类药物也是如此；在对临床特征进行逻辑回归分析后，这种关系依然存在。
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