一种从枳壳干燥幼果中提取的新黄酮苷。

A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata.

作者信息

Han Ah-Reum, Kim Jong-Bin, Lee Jun, Nam Joo-Won, Lee Ik-Soo, Shim Chang-Koo, Lee Kyung-Tae, Seo Eun-Kyoung

机构信息

College of Pharmacy and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea.

出版信息

Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1270-3. doi: 10.1248/cpb.55.1270.

DOI:10.1248/cpb.55.1270

PMID:17666859

Abstract

A new flavanone glycoside, (2R)-5-hydroxy-4'-methoxyflavanone-7-O-{beta-glucopyranosyl-(1-->2)-beta-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E(2) (PGE(2)) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.

摘要

从枳实的乙酸乙酯提取物中分离出一种新的黄酮苷，(2R)-5-羟基-4'-甲氧基黄酮-7-O-{β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖苷}(1)，以及三种已知化合物，(2S)-枳属苷(2)、(2S)-柚皮苷(3)和(2S)-枳属素(4)。通过光谱数据分析，包括一维和二维核磁共振实验，阐明了化合物1的结构。在分离出的化合物中，化合物2对脂多糖(LPS)诱导的前列腺素E2(PGE2)和白细胞介素-6(IL-6)的产生以及RAW 264.7小鼠巨噬细胞中的mRNA表达表现出相当强的抑制活性。