Cheng Haiying, Duong Timothy Q
Yerkes Imaging Center, Department of Neurology, Emory University, Atlanta, Georgia 30329, USA.
Opt Lett. 2007 Aug 1;32(15):2188-90. doi: 10.1364/ol.32.002188.
Laser speckle imaging (LSI) is widely used to study blood flow at high spatiotemporal resolution. Several papers recently pointed out that the commonly used LSI equation involves an approximation that could result in incorrect data analysis. We investigated the impact of such an approximation and introduced a simplified analysis method to improve computation time. Flow phantom studies were performed for validation. Moreover, we demonstrated a novel LSI application by imaging blood flow of rat retinas under normal and physiologic-challenge conditions. Because blood-flow abnormality is implicated in many retinal diseases, LSI could provide valuable physiologic, and potentially diagnostic, information.
激光散斑成像（LSI）被广泛用于以高时空分辨率研究血流。最近有几篇论文指出，常用的LSI方程涉及一种近似，这可能导致数据分析不正确。我们研究了这种近似的影响，并引入了一种简化的分析方法来缩短计算时间。进行了流动模型研究以进行验证。此外，我们通过对正常和生理挑战条件下大鼠视网膜的血流进行成像，展示了一种新颖的LSI应用。由于血流异常与许多视网膜疾病有关，LSI可以提供有价值的生理信息，并可能具有诊断价值。
