激光散斑图像的时间统计分析及其在视网膜血流成像中的应用。
Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging.
作者信息
Cheng Haiying, Yan Yumei, Duong Timothy Q
机构信息
Yerkes Imaging Center and Department of Neurology, Emory University, Atlanta, Georgia, 30329, USA.
出版信息
Opt Express. 2008 Jul 7;16(14):10214-9. doi: 10.1364/oe.16.010214.
Abstract
Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatial-statistical analysis (SS-LSI). Concerns have been raised regarding the temporal independency of TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms and in vivo rat retinas demonstrated that the TS-LSI signals are temporally statistically independent and TS-LSI minimizes stationary-speckle contamination. The latter is because the stationary speckle is "non-random" and thus non-ergodic where the temporal average of stationary speckle needs not equal its spatial ensemble average. TS-LSI detects blood flow in smaller blood vessels and is less susceptible to stationary-speckle artifacts.
摘要
与传统的空间统计分析（SS-LSI）相比，激光散斑图像的时间统计分析（TS-LSI）保留了原始空间分辨率。人们对TS-LSI信号的时间独立性及其对静止散斑污染的不敏感性提出了担忧。我们在流动模型和体内大鼠视网膜上的研究结果表明，TS-LSI信号在时间上具有统计独立性，并且TS-LSI可将静止散斑污染降至最低。后者是因为静止散斑是“非随机的”，因此是非遍历性的，静止散斑的时间平均值不一定等于其空间总体平均值。TS-LSI能够检测较小血管中的血流，并且不易受到静止散斑伪影的影响。
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