Ozaki Katsutoshi, Sato Kazuya, Oh Iekuni, Meguro Akiko, Tatara Raine, Muroi Kazuo, Ozawa Keiya
Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Int J Hematol. 2007 Jul;86(1):5-7. doi: 10.1532/IJH97.07003.
Mesenchymal stem cells (MSCs) have been identified in animals, especially in bone marrow. As stem cells, they have the ability to differentiate into multiple cell types. This potential raises exciting therapeutic possibilities. A recent report described the successful use of MSCs for the treatment of graft-versus-host disease; however, the scientific community has yet to define the molecular mechanisms of immunomodulation by MSCs. This review summarizes what is known and discusses the conflicting data with regard to the mechanisms of immunomodulation by MSCs.
间充质干细胞（MSCs）已在动物体内被鉴定出来，尤其是在骨髓中。作为干细胞，它们具有分化为多种细胞类型的能力。这种潜能带来了令人兴奋的治疗可能性。最近一份报告描述了MSCs在治疗移植物抗宿主病方面的成功应用；然而，科学界尚未明确MSCs免疫调节的分子机制。本综述总结了已知的内容，并讨论了关于MSCs免疫调节机制的相互矛盾的数据。
