Abarbanel J, Shabtai F, Kyzer S, Chaimof C
Department of Surgery A, Golda Medical Center, Hasharon Hospital, Petah Tiqva, Israel.
World J Surg. 1991 Nov-Dec;15(6):778-82. doi: 10.1007/BF01665318.
Banded cytogenetic studies of gastric carcinoma are still relatively scarce, comprised of only a small number of patients. This study was performed on peripheral blood lymphocytes and malignant cells of 16 patients with gastric carcinoma. The lymphocytes were analyzed by standard techniques. All patients had a normal constitutional karyotype; 90% of the patients presented an increased breakage rate and nonrandom chromosomal instability mainly in the heterochromatic regions of chromosomes 1, 9, and 16. Decreased response to phytohemagglutinin was observed in 6 (38%) patients. The tissue specimens were analyzed using direct techniques. Normal ploidy was observed in only one patient, 3 tumors were near-diploid, 4 hyperdiploid, 4 near-triploid, and 4 near-tetraploid. Those with the near-triploid or near-tetraploid constitution were in a more advanced pathological stage, most of them with a more complex cytogenetic profile. Particular involvement was found for chromosomes 1 to 4, 7 to 9, 17, and 20, but the more specific nonrandom changes seemed to involve chromosomes 7, 8, 9, and 17.
胃癌的带型细胞遗传学研究仍然相对较少，仅涉及少数患者。本研究对16例胃癌患者的外周血淋巴细胞和恶性细胞进行了检测。淋巴细胞采用标准技术进行分析。所有患者的染色体核型均正常；90%的患者出现断裂率增加和非随机染色体不稳定，主要发生在1号、9号和16号染色体的异染色质区域。6例（38%）患者对植物血凝素的反应降低。组织标本采用直接技术进行分析。仅1例患者观察到正常倍体，3个肿瘤为近二倍体，4个为超二倍体，4个为近三倍体，4个为近四倍体。具有近三倍体或近四倍体核型的患者处于更晚期的病理阶段，其中大多数具有更复杂的细胞遗传学特征。发现1至4号、7至9号、17号和20号染色体有特殊受累情况，但更具特异性的非随机变化似乎涉及7号、8号、9号和17号染色体。
