Szekeres-Bartho J, Kinsky R, Kapovic M, Chaouat G
Institute of Microbiology, University Medical School, Pecs, Hungary.
Am J Reprod Immunol. 1991 Sep;26(2):82-3. doi: 10.1111/j.1600-0897.1991.tb00976.x.
Treatment of pregnant CBA/J females with CFA at day 0.5 and 7.5 of pregnancy significantly reduced the fetal resorption rates from 45% to 29% (P less than 0.05). Supernatants of progesterone-treated spleen cells from CFA treated CBA/J females pregnant of DBA/2 males significantly reduced natural cytotoxicity, while those of untreated identically pregnant mice had no effect. Supernatants of CFA-treated virgin mice blocked natural cytotoxicity to the same extent as those of CFA-treated pregnant mice. These data suggest that nonspecific immunostimulation induces progesterone receptors in spleen cells of CBA mice and that these receptors allow a progesterone dependent suppressive pathway to exert an antiresorptive effect.
在妊娠第0.5天和7.5天用完全弗氏佐剂（CFA）处理CBA/J孕鼠，可使胎儿吸收率从45%显著降低至29%（P<0.05）。用孕酮处理来自与DBA/2雄鼠交配的经CFA处理的CBA/J孕鼠的脾细胞上清液，可显著降低自然细胞毒性，而未经处理的同孕小鼠的脾细胞上清液则无此作用。经CFA处理的处女鼠的脾细胞上清液与经CFA处理的孕鼠的脾细胞上清液一样，能在相同程度上阻断自然细胞毒性。这些数据表明，非特异性免疫刺激可诱导CBA小鼠脾细胞中的孕酮受体，且这些受体可使孕酮依赖性抑制途径发挥抗吸收作用。
