吲哚美辛在母乳中的排泄。
Excretion of indomethacin in breast milk.
作者信息
Lebedevs T H, Wojnar-Horton R E, Yapp P, Roberts M J, Dusci L J, Hackett L P, Ilett K F
机构信息
Department of Pharmacy, King Edward Memorial Hospital for Women, Subiaco, Western Australia.
出版信息
Br J Clin Pharmacol. 1991 Dec;32(6):751-4.
Abstract
- The excretion of indomethacin into breast milk and subsequent exposure of infants was studied in 16 women and seven of their infants. The median milk:plasma ratio in seven patients where there were measurable drug concentrations in both milk and plasma was 0.37. 2. Total infant dose, assuming a daily milk intake of 150 ml kg-1 and 100% absorption, ranged from 0.07% to 0.98% (median = 0.18%) of the weight adjusted maternal dose. 3. Plasma samples were obtained in seven infants. In six of these, indomethacin concentrations were below the sensitivity of the assay (less than 20 micrograms l-1), while one infant had a plasma indomethacin concentration of 47 micrograms l-1. 4. No adverse effects due to indomethacin were reported in the infants.
摘要
- 对16名女性及其7名婴儿进行了研究，以了解吲哚美辛在母乳中的排泄情况以及婴儿随后的暴露情况。在7名母乳和血浆中均有可测量药物浓度的患者中，母乳与血浆的中位比值为0.37。2. 假设每日母乳摄入量为150 ml/kg且吸收率为100%，婴儿的总剂量范围为体重校正后母亲剂量的0.07%至0.98%（中位数=0.18%）。3. 采集了7名婴儿的血浆样本。其中6名婴儿的吲哚美辛浓度低于检测灵敏度（低于20μg/L），而1名婴儿的血浆吲哚美辛浓度为47μg/L。4. 未报告婴儿因吲哚美辛出现不良反应。
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