Kiran Kumar K, Saraswathi T R, Ranganathan K, Uma Devi M, Elizabeth Joshua
Department of Oral and Maxillofacial Pathology, SDM College of Dental Science and Hospital, Sattur, Dharwad - 580 007, India.
Indian J Dent Res. 2007 Jul-Sep;18(3):106-11. doi: 10.4103/0970-9290.33785.
Oral submucous fibrosis (OSF) is a precancerous condition associated with the use of areca nut in various forms. There are very few reports to correlate the clinical stage to histopathological grading in OSF.
A hospital-based study was conducted on 75 OSF cases who visited our hospital in Chennai from 2000-2003. A detailed history of each patient was recorded along with a clinical examination. Biopsy was performed for histopathological correlation. Clinical stage of the disease in terms of the ability to open one's mouth was correlated with histopathological grading.
The male to female ratio of OSF cases was 6:1. All forms of areca nut products were associated with OSF. Chewing of paanmasala was associated with early presentation of OSF as compared to chewing of the betel nut. Out of 57 cases, which were in clinical stage II, 91.2% had histological grading of I and II in equal proportions and 8.8% had histological grade III. Out of 13 cases that showed a clinical stage of III, 52% showed a histological grade of II, 40% grade III and 8% grade I.
In the present study, there was no direct correlation between clinical stages and histopathological grading. The possibility of difference in the severity and extent of fibrosis in different regions of the oral mucosa and involved muscles were considered as contributory factors for this variation.
口腔黏膜下纤维化（OSF）是一种与多种形式槟榔使用相关的癌前病变。很少有报告将OSF的临床分期与组织病理学分级相关联。
对2000年至2003年期间在金奈我院就诊的75例OSF患者进行了一项基于医院的研究。记录了每位患者的详细病史并进行了临床检查。进行活检以进行组织病理学关联。根据张口能力确定的疾病临床分期与组织病理学分级相关联。
OSF患者的男女比例为6:1。所有形式的槟榔制品都与OSF相关。与咀嚼槟榔相比，咀嚼masala槟榔与OSF的早期表现相关。在57例临床II期病例中，91.2%的组织学分级为I级和II级，比例相等，8.8%为组织学III级。在13例临床III期病例中，52%的组织学分级为II级，40%为III级，8%为I级。
在本研究中，临床分期与组织病理学分级之间没有直接关联。口腔黏膜不同区域和受累肌肉中纤维化的严重程度和范围存在差异的可能性被认为是导致这种差异的因素。
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