Department of Basic and Applied Biology, University of L'Aquila, 67100 L'Aquila, Italy.
PPAR Res. 2007;2007:48242. doi: 10.1155/2007/48242.
PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription factors which regulate specific sets of specialized genes to allow proliferative cells to exit the cell cycle and acquire specialized functions. The main differentiation programs known to be controlled by PPARs both during development and in the adult are placental differentiation, adipogenesis, osteoblast differentiation, skin differentiation, and gut differentiation. PPARs may also be involved in the differentiation of macrophages, brain, and breast. However, their functions in this cell type and organs still awaits further elucidation. PPARs may be involved in cell proliferation and differentiation processes of neural stem cells (NSC). To this aim, in this work the expression of the three PPAR isotypes and RXRs in NSC has been investigated.
PPAR 异构体参与细胞增殖、死亡和分化的调节，其具体作用和机制取决于特定的异构体和配体，以及细胞的分化、未分化或转化状态。分化刺激物由关键转录因子整合，这些转录因子调节特定的一组特化基因，使增殖细胞退出细胞周期并获得特化功能。在发育和成年过程中，已知受 PPAR 控制的主要分化程序包括胎盘分化、脂肪生成、成骨细胞分化、皮肤分化和肠道分化。PPAR 也可能参与巨噬细胞、大脑和乳腺的分化。然而，它们在这些细胞类型和器官中的功能仍有待进一步阐明。PPAR 可能参与神经干细胞 (NSC) 的细胞增殖和分化过程。为此，在这项工作中研究了 NSC 中三种 PPAR 异构体和 RXR 的表达。
