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抗原生动物寄生虫的DNA疫苗:进展与挑战

DNA Vaccines against Protozoan Parasites: Advances and Challenges.

作者信息

Dumonteil Eric

机构信息

Laboratorio de Parasitología, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, 97000 Mérida, Yucatán, Mexico.

出版信息

J Biomed Biotechnol. 2007;2007(6):90520. doi: 10.1155/2007/90520.

Abstract

Over the past 15 years, DNA vaccines have gone from a scientific curiosity to one of the most dynamic research field and may offer new alternatives for the control of parasitic diseases such as leishmaniasis and Chagas disease. We review here some of the advances and challenges for the development of DNA vaccines against these diseases. Many studies have validated the concept of using DNA vaccines for both protection and therapy against these protozoan parasites in a variety of mouse models. The challenge now is to translate what has been achieved in these models into veterinary or human vaccines of comparable efficacy. Also, genome-mining and new antigen discovery strategies may provide new tools for a more rational search of novel vaccine candidates.

摘要

在过去的15年里,DNA疫苗已从科学上的新奇事物发展成为最具活力的研究领域之一,并可能为控制利什曼病和恰加斯病等寄生虫病提供新的选择。我们在此回顾针对这些疾病开发DNA疫苗的一些进展和挑战。许多研究已在多种小鼠模型中验证了使用DNA疫苗预防和治疗这些原生动物寄生虫的概念。现在面临的挑战是将在这些模型中取得的成果转化为具有同等效力的兽用或人用疫苗。此外,基因组挖掘和新抗原发现策略可能为更合理地寻找新型候选疫苗提供新工具。

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