Wang Lin, O'Donoghue Meghan B, Tan Weihong
University of Florida, Center for Research at the Bio/Nano Interface, Department of Chemistry, Shands Cancer Center and UF Genetics Institute, Gainesville, FL 32611, USA.
Nanomedicine (Lond). 2006 Dec;1(4):413-26. doi: 10.2217/17435889.1.4.413.
The drive to understand biology and medicine at the molecular level with accurate quantitation demands much of current high-throughput analysis systems. Nanomaterials and nanotechnology combined with modern instrumentation have the potential to address this emerging challenge. Using a variety of nanomaterials for multiplex diagnostics and imaging applications will offer sensitive, rapid and cost-effective solutions for the modern clinical laboratory. New nanomaterials have been developed with optical-encoding capabilities for selective tagging of a wide range of medically important targets, including bacteria, cancer cells and individual molecules, such as proteins and DNA, in a single assay. We envision further development in this field will provide numerous advanced tools with increased sensitivity and improved multiplexing capability, for unique applications in molecular biology, genomics and drug discovery.
在分子水平上准确量化地理解生物学和医学的需求对当前的高通量分析系统提出了很高要求。纳米材料和纳米技术与现代仪器相结合有潜力应对这一新兴挑战。使用各种纳米材料进行多重诊断和成像应用将为现代临床实验室提供灵敏、快速且经济高效的解决方案。已开发出具有光学编码能力的新型纳米材料，可在单次检测中对包括细菌、癌细胞以及蛋白质和DNA等单个分子在内的多种医学重要靶点进行选择性标记。我们设想该领域的进一步发展将提供众多具有更高灵敏度和改进多重分析能力的先进工具，用于分子生物学、基因组学和药物发现等独特应用。
