噬菌体在伯克霍尔德菌致病机制中的作用，或“伯克霍尔德菌噬菌体中的毒素基因在哪里？”
Role of phages in the pathogenesis of Burkholderia, or 'Where are the toxin genes in Burkholderia phages?'.
作者信息
Summer Elizabeth J, Gill Jason J, Upton Chris, Gonzalez Carlos F, Young Ry
机构信息
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, United States.
出版信息
Curr Opin Microbiol. 2007 Aug;10(4):410-7. doi: 10.1016/j.mib.2007.05.016. Epub 2007 Aug 23.
Most bacteria of the genus Burkholderia are soil- and rhizosphere-associated, and rhizosphere associated, noted for their metabolic plasticity in the utilization of a wide range of organic compounds as carbon sources. Many Burkholderia species are also opportunistic human and plant pathogens, and the distinction between environmental, plant, and human pathogens is not always clear. Burkholderia phages are not uncommon and multiple cryptic prophages are identifiable in the sequenced Burkholderia genomes. Phages have played a crucial role in the transmission of virulence factors among many important pathogens; however, the data do not yet support a significant correlation between phages and pathogenicity in the Burkholderia. This may be due to the role of Burkholderia as a 'versaphile' such that selection is occurring in several niches, including as a pathogen and in the context of environmental survival.
伯克霍尔德氏菌属的大多数细菌与土壤和根际相关，以其在利用多种有机化合物作为碳源方面的代谢可塑性而闻名。许多伯克霍尔德氏菌也是机会性人类和植物病原体，环境、植物和人类病原体之间的区别并不总是很清楚。伯克霍尔德氏菌噬菌体并不罕见，在已测序的伯克霍尔德氏菌基因组中可识别出多个隐匿性原噬菌体。噬菌体在许多重要病原体的毒力因子传播中发挥了关键作用；然而，目前的数据尚不支持噬菌体与伯克霍尔德氏菌致病性之间存在显著相关性。这可能是由于伯克霍尔德氏菌作为一种“嗜多种环境菌”的作用，使得选择发生在几个生态位中，包括作为病原体以及在环境生存的背景下。
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