三维空间中自分泌信号的时间和长度尺度。
Time and length scales of autocrine signals in three dimensions.
作者信息
Coppey Mathieu, Berezhkovskii Alexander M, Sealfon Stuart C, Shvartsman Stanislav Y
机构信息
Department of Chemical Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
出版信息
Biophys J. 2007 Sep 15;93(6):1917-22. doi: 10.1529/biophysj.107.109736.
Abstract
A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.
摘要
基于有效介质近似，建立了悬浮细胞培养中自分泌信号传导的模型。推导出自分泌配体的比例、旁分泌配体在结合前传播的距离的均值和分布，以及配体寿命的均值和分布。以树突状免疫细胞的干扰素信号传导为例进行说明。
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