脑室内微量注射前列腺素内过氧化物的稳定类似物可使家兔发热。
Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits.
作者信息
Harrisberg C J, Laburn H, Mitchell D
出版信息
J Physiol. 1979 Jun;291:29-35. doi: 10.1113/jphysiol.1979.sp012797.
Abstract
- Derivatives of arachidonic acid other than prostaglandin are pyrogenic, the likely candidates being the prostaglandin endoperoxides and/or the thromboxanes. 2. Intraventricular microinjections in rabbits of a stable analogue of prostaglandin endoperoxide resulted in dose-dependent increases of rectal temperature. The pyrexia was delayed in onset; no significant change in body temperature occurred for at least an hour. 3. The pyrexia was unaltered by simultaneous injection of the potent prostaglandin synthetase inhibitor indomethacin. 4. We suggest that both prostaglandins and prostaglandin endoperoxides may be implicated in fever.
摘要
- 除前列腺素外，花生四烯酸的衍生物具有致热作用，可能的候选物质是前列腺素内过氧化物和/或血栓素。2. 给家兔脑室内微量注射前列腺素内过氧化物的一种稳定类似物，可导致直肠温度呈剂量依赖性升高。发热起效延迟；至少1小时内体温无明显变化。3. 同时注射强效前列腺素合成酶抑制剂吲哚美辛，发热无改变。4. 我们认为，前列腺素和前列腺素内过氧化物都可能与发热有关。
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本文引用的文献
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The central respiratory stimulant action of salicylates.水杨酸盐的中枢呼吸刺激作用。
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Biochem Biophys Res Commun. 1974 Dec 11;61(3):942-9. doi: 10.1016/0006-291x(74)90246-0.
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Bronchopulmonary pharmacology of some prostaglandin endoperoxide analogs in the dog.犬体内某些前列腺素内过氧化物类似物的支气管肺药理学
Eur J Pharmacol. 1976 Mar;36(1):103-14. doi: 10.1016/0014-2999(76)90262-4.
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A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.脑脊液中发热与前列腺素浓度之间的分离。
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