Ruthotto F, Papendorf F, Wegener G, Unger G, Dlugosch B, Korangy F, Manns M P, Greten T F
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.
Ann Oncol. 2007 Sep;18(9):1518-22. doi: 10.1093/annonc/mdm200.
Current guidelines recommend screening colonoscopy in first-degree relatives of patients with colon cancer. The aim of this state-wide study was to investigate the compliance for colonoscopic in first-degree relatives, who were younger than 60 years of age.
A total of 602 patients were identified from the tumor registry of the public health insurance of Lower Saxony. A questionnaire was sent to these patients, which included a number of different questions regarding their knowledge about the risk of colon cancer for their family members, as well as their participation in screening colonoscopy.
Data from 442 patients and their first-degree relatives (1005 siblings and 354 parents) were available; 178 parents had undergone screening colonoscopy and 344 siblings. Interestingly, the percentage of siblings who underwent screening colonoscopy was significantly higher (27%) among those siblings where the index patients were aware of the increased risk for the first-degree relatives, in contrast to the siblings of the index patients who were not aware of this risk (20%).
This study demonstrates that only a minority of first-degree relatives undergo screening colonoscopy and that informing patients about the potential risk for their relatives will increase participation in screening colonoscopy in first-degree relatives of the patients.
当前指南推荐对结肠癌患者的一级亲属进行结肠镜筛查。这项全州范围研究的目的是调查年龄小于60岁的一级亲属接受结肠镜检查的依从性。
从下萨克森州公共医疗保险的肿瘤登记处识别出602名患者。向这些患者发送了一份问卷,其中包括一些关于他们对家庭成员患结肠癌风险的了解以及他们参与结肠镜筛查情况的不同问题。
获得了442名患者及其一级亲属(1005名兄弟姐妹和354名父母)的数据;178名父母和344名兄弟姐妹接受了结肠镜筛查。有趣的是,在索引患者意识到一级亲属患病风险增加的那些兄弟姐妹中,接受结肠镜筛查的兄弟姐妹比例(27%)显著高于索引患者未意识到此风险的兄弟姐妹(20%)。
这项研究表明,只有少数一级亲属接受结肠镜筛查,并且告知患者其亲属的潜在风险将增加患者一级亲属参与结肠镜筛查的比例。