Steiger A, von Bardeleben U, Wiedemann K, Holsboer F
Department of Psychiatry, University of Mainz, Germany.
J Psychiatr Res. 1991;25(4):169-77. doi: 10.1016/0022-3956(91)90021-2.
Sleep EEG and the nocturnal secretion of cortisol and testosterone in 12 male patients (mean age 46.4 +/- 11.26 years) with major endogenous depression were investigated concomitantly during acute depression, before treatment and after recovery and drug cessation. Testosterone concentration increased after remission, while cortisol secretion decreased. Sleep EEG disturbances remained unchanged in remitted patients. The data suggest that a blunted testosterone and an elevated cortisol secretion are state markers of acute depression, which normalize independently from sleep structure. An interaction between the hypothalamic-pituitary-gonadal axis and the limbic-hypothalamic-pituitary-adrenocortical axis appears likely.
对12名患有严重内源性抑郁症的男性患者（平均年龄46.4±11.26岁）在急性抑郁期、治疗前、康复及停药后同时进行睡眠脑电图以及皮质醇和睾酮夜间分泌情况的研究。缓解后睾酮浓度升高，而皮质醇分泌减少。缓解期患者的睡眠脑电图紊乱情况保持不变。数据表明，睾酮分泌减弱和皮质醇分泌升高是急性抑郁的状态标志物，它们独立于睡眠结构而恢复正常。下丘脑-垂体-性腺轴与边缘系统-下丘脑-垂体-肾上腺皮质轴之间似乎存在相互作用。
