Delfino-Machín Mariana, Chipperfield Thomas R, Rodrigues Frederico S L M, Kelsh Robert N
Centre for Regenerative Medicine and Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
Dev Dyn. 2007 Dec;236(12):3242-54. doi: 10.1002/dvdy.21314.
Neural crest stem cells were first isolated from early embryonic neural crest in the early 1990s, but in the past 5 years, there has been a burst of discoveries of neural crest-derived stem cells from diverse locations. Here, we summarize these data, highlighting the characteristics of each stem cell type. These cells vary widely in the markers they express and the variety of cell types they appear to generate. They occupy diverse locations, but in some cases multiple stem cell types apparently occupy physically proximate niches. To date, few molecular similarities can be identified between these stem cells, although a systematic comparison is required. We note other issues worthy of attention, including aspects of the in vivo behavior of these stem cells, their niches, and their lineage relationships. Together, analysis of these issues will clarify this expanding, but still young, field and contribute to exploration of the important therapeutic potential of these cells.
神经嵴干细胞最初是在20世纪90年代初从早期胚胎神经嵴中分离出来的，但在过去5年里，人们从不同位置发现了大量神经嵴衍生的干细胞。在此，我们总结这些数据，突出每种干细胞类型的特征。这些细胞在表达的标志物以及它们似乎能产生的细胞类型的多样性方面差异很大。它们占据着不同的位置，但在某些情况下，多种干细胞类型显然占据着物理上相邻的生态位。迄今为止，尽管需要进行系统比较，但在这些干细胞之间几乎找不到分子相似性。我们还指出了其他值得关注的问题，包括这些干细胞在体内的行为、它们的生态位以及它们的谱系关系等方面。综合起来，对这些问题的分析将阐明这个不断扩展但仍处于起步阶段的领域，并有助于探索这些细胞重要的治疗潜力。
