健康志愿者急性前额叶皮质经颅磁刺激：对血清中脑源性神经营养因子（BDNF）浓度无影响。
Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers: no effects on brain-derived neurotrophic factor (BDNF) concentrations in serum.
作者信息
Lang Undine E, Hellweg Rainer, Gallinat Juergen, Bajbouj Malek
机构信息
Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.
出版信息
J Affect Disord. 2008 Apr;107(1-3):255-8. doi: 10.1016/j.jad.2007.08.008. Epub 2007 Sep 7.
BACKGROUND
Transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex is a brain stimulation technique widely used to treat depression. BDNF serum concentrations have been shown to be decreased in patients with major depressive disorder and can be upregulated by several antidepressive treatment strategies including repetitive TMS.
METHODS
In this study we were interested whether acute TMS evolves effects on serum BDNF concentrations in 42 healthy volunteers.
RESULTS
Mean BDNF serum concentration in 19 male and 23 female volunteers was 10.70+/-3.6 ng/ml (n=42) at baseline, and 10.76+/-3.9 ng/ml (n=42) after TMS treatment. BDNF serum levels did not change after acute TMS (n=42, Z=-0.44, p=0.965). BDNF serum concentrations at baseline did not differ between male (n=19, 10.05+/-2.6 ng/ml) and female (n=23, 11.25+/-4.27 ng/ml) participants of the study (n=42, Z=-0.91, p=0.363).
CONCLUSIONS
Our result suggests that TMS does not change BDNF serum concentrations immediately in healthy human volunteers.
背景
经颅磁刺激（TMS）背外侧前额叶皮层是一种广泛用于治疗抑郁症的脑刺激技术。已有研究表明，重度抑郁症患者血清脑源性神经营养因子（BDNF）浓度降低，且包括重复经颅磁刺激在内的多种抗抑郁治疗策略可使其上调。
方法
在本研究中，我们探究了急性经颅磁刺激对42名健康志愿者血清BDNF浓度是否有影响。
结果
19名男性和23名女性志愿者的血清BDNF平均浓度在基线时为10.70±3.6 ng/ml（n = 42），经颅磁刺激治疗后为10.76±3.9 ng/ml（n = 42）。急性经颅磁刺激后血清BDNF水平未发生变化（n = 42，Z = -0.44，p = 0.965）。研究中的男性参与者（n = 19，10.05±2.6 ng/ml）和女性参与者（n = 23，11.25±4.27 ng/ml）的基线血清BDNF浓度无差异（n = 42，Z = -0.91，p = 0.363）。
结论
我们的结果表明，经颅磁刺激不会立即改变健康人类志愿者的血清BDNF浓度。
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