2型糖尿病患者的血浆矿物质含量及其与代谢综合征的关联。
Plasma mineral content in type-2 diabetic patients and their association with the metabolic syndrome.
作者信息
Aguilar M V, Saavedra P, Arrieta F J, Mateos C J, González M J, Meseguer I, Martínez-Para M C
机构信息
Department of Nutrition, Bromatology and Toxicology, Faculty of Pharmacy, University of Alcalá, Madrid, Spain.
出版信息
Ann Nutr Metab. 2007;51(5):402-6. doi: 10.1159/000108108. Epub 2007 Sep 11.
BACKGROUND
Metabolic syndrome is a clinical disorder that is becoming more prevalent in Spain. The syndrome encompasses a set of metabolic disorders such as type-2 diabetes mellitus, hypertension, dyslipidemia, and obesity, which may be associated with variations in serum levels and poor delivery of certain mineral elements.
METHODS
This study attempted to ascertain whether metabolic syndrome might be linked to alterations in serum levels of the mineral elements magnesium, copper, zinc, chromium, and nickel in a population of 92 diabetic subjects, some suffering from certain conditions associated with the metabolic syndrome, and 72 control subjects (Hospital Príncipe de Asturias, Alcalá de Henares, Spain).
RESULTS
The results indicated that as a group the alterations implicated in metabolic syndrome were indeed associated with variations in blood levels of the mineral elements considered, though statistically significant differences were recorded only in the case of copper. Still, trends in mineral levels for each of the separate components contributing to the syndrome tended to increase.
CONCLUSION
Metabolic complications appear to be associated with alterations in the levels of some minerals, especially copper.
背景
代谢综合征是一种临床病症，在西班牙正变得越来越普遍。该综合征包含一系列代谢紊乱，如2型糖尿病、高血压、血脂异常和肥胖，这些可能与某些矿物质元素的血清水平变化及供应不足有关。
方法
本研究试图确定在92名糖尿病患者（其中一些患有与代谢综合征相关的某些病症）和72名对照受试者（西班牙阿尔卡拉德埃纳雷斯阿斯图里亚斯王子医院）组成的人群中，代谢综合征是否可能与矿物质元素镁、铜、锌、铬和镍的血清水平变化有关。
结果
结果表明，作为一个整体，代谢综合征所涉及的改变确实与所考虑的矿物质元素的血液水平变化有关，尽管仅在铜的情况下记录到了具有统计学意义的差异。不过，构成该综合征的各个单独成分的矿物质水平趋势往往会升高。
结论
代谢并发症似乎与某些矿物质水平的改变有关，尤其是铜。
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